Results 1 to 10 of about 2,671,764 (310)

Epidemiology, etiology and treatment of gastroparesis: real-world evidence from a large US national claims database.

Gastroenterology, 2021
BACKGROUND & AIMS While gastroparesis carries a considerable healthcare and patient burden, associated epidemiological data are limited. To provide new real-world evidence for gastroparesis, we estimated disease prevalence, and investigated patient ...
Y. Ye, Y. Yin, S. Huh, C. Almansa, D. Bennett, M. Camilleri   +5 more
semanticscholar   +1 more source

Real-world evidence for regulatory decision-making: updated guidance from around the world

Frontiers in Medicine, 2023
Leveraging the value of real-world evidence (RWE) to make informed regulatory decisions in the field of health care continues to gain momentum. Improving clinical evidence generation by evaluating the outcomes and patient experiences at the point-of-care
L. Burns, N. Le Roux, Robert Kalesnik-Orszulak, Jennifer Christian, Jennifer Dudinak, Frank Rockhold, S. Khozin, J. O’Donnell   +7 more
semanticscholar   +1 more source

Automating Access to Real-World Evidence

JTO Clinical and Research Reports, 2022
Real-world evidence is important in regulatory and funding decisions. Manual data extraction from electronic health records (EHRs) is time-consuming and challenging to maintain. Automated extraction using natural language processing (NLP) and artificial intelligence may facilitate this process.
Marie-Pier Gauthier, MD, Jennifer H. Law, MSc, Lisa W. Le, MSc, Janice J.N. Li, BSc, Sajda Zahir, Sharon Nirmalakumar, BSc, Mike Sung, MD, Christopher Pettengell, BMBCh, Steven Aviv, BBusSc, Ryan Chu, MD, Adrian Sacher, MD, MSc, Geoffrey Liu, MD, MSc, Penelope Bradbury, MBChB, Frances A. Shepherd, MD, Natasha B. Leighl, MD, MMSc, FRCPC, FASCO   +14 more
openaire   +3 more sources

Metformin and Cancer: Solutions to a Real-World Evidence Failure.

Diabetes Care, 2023
The quest to repurpose metformin, an antidiabetes drug, as an agent for cancer prevention and treatment, which began in 2005 with an observational study that reported a reduction in cancer incidence among metformin users, generated extensive experimental,
O. Yu, S. Suissa
semanticscholar   +1 more source

Decrease in rate of multiple sclerosis-related hospitalizations in Portugal [version 1; referees: 2 approved]

F1000Research, 2016
We sought to investigate the rate of multiple sclerosis (MS)-related hospitalizations in Portugal and assess whether there have been temporal changes as described in other countries. Using data from the Portuguese National Discharge Registry, we observed
Marta Pereira, Dimitra Lambrelli, Sreeram V. Ramagopalan   +2 more
doaj   +1 more source

Validation of algorithms to identify colorectal cancer patients from administrative claims data of a Japanese hospital

BMC Health Services Research, 2023
Background Administrative claims data are a valuable source for clinical studies; however, the use of validated algorithms to identify patients is essential to minimize bias.
Takahiro Hirano, Makiko Negishi, Yoshiki Kuwatsuru, Masafumi Arai, Ryozo Wakabayashi, Naoko Saito, Ryohei Kuwatsuru   +6 more
doaj   +1 more source

Biologics for severe asthma: The real-world evidence, effectiveness of switching, and prediction factors for the efficacy.

Allergology International, 2022
Biologics have been a key component of severe asthma treatment, and there are currently biologics available that target IgE, IL-5, IL-4/IL-13, and TSLP.
H. Nagase, M. Suzukawa, K. Oishi, K. Matsunaga   +3 more
semanticscholar   +1 more source

Effectiveness and safety of recombinant zoster vaccine: A review of real-world evidence

Human Vaccines & Immunotherapeutics, 2023
The recombinant zoster vaccine (RZV) was licensed in the US for prevention of herpes zoster (HZ) in 2017. We conducted a literature search (January 1, 2017–August 1, 2023) using PubMed, Embase, and Scopus to consolidate the real-world evidence related to
Raunak Parikh, David Singer, Elizabeth Chmielewski-Yee, Christophe Dessart   +3 more
semanticscholar   +1 more source

Integration of real-world evidence from different data sources in health technology assessment

Journal of Pharmacy & Pharmaceutical Sciences, 2023
Real-world evidence (RWE) is being increasingly used by a wide range of stakeholders involved in the therapeutic product lifecycle but remains underutilized in the health technology assessment (HTA) process.
P. Graili, J. Guertin, Kelvin K. W. Chan, Mina Tadrous   +3 more
semanticscholar   +1 more source

Real‐world evidence on the utilization, clinical and comparative effectiveness, and adverse effects of newer GLP‐1RA‐based weight‐loss therapies

Diabetes, obesity and metabolism
Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have emerged as key agents for weight management, based on their marked efficacy as observed in randomized controlled trials.
R. Thomsen, Aurélie Mailhac, J. B. Løhde, A. Pottegård   +3 more
semanticscholar   +1 more source