Results 31 to 40 of about 3,960,591 (302)

Application of Big Data to Support Evidence-Based Public Health Policy Decision-Making for Hearing [PDF]

, 2020
Ideally, public health policies are formulated from scientific data; however, policy-specific data are often unavailable. Big data can generate ecologically-valid, high-quality scientific evidence, and therefore has the potential to change how public ...
Andermann, Barker, Basu, Benke, Choi, Christensen, Deiner, Dritsakis, Ferguson, Gatehouse, Greer, Gutenberg, Hernandez, Horsman, Howell, Katrakazas, Kehler, Konstantopoulos, Larsen, Lee, Livingston, Luo, Mahmoudi, Mellor, Michopoulos, Mooney, Moyer, Murdoch, Nasreddine, Obermeyer, Oliver, Orton, Polanczyk, Raghupathi, Reavis, Salathé, Schilder, Shardell, Shiffrin, Topol, Tu, Ullah, van de Goor, Vos, Willink, Yaffe, Young, Zigmond   +47 more
core   +3 more sources

Treatment pathways, economic burden and clinical outcomes in new users of inhaled corticosteroid/long-acting B2-agonist dual therapy with chronic obstructive pulmonary disease in a primary care setting in England: a retrospective cohort study

BMJ Open
Objective Management of chronic obstructive pulmonary disease (COPD) with inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) improves lung function and health status and reduces COPD exacerbation risk versus monotherapy.
Victoria Banks, Robert Wood, Gema Requena, Alexandrosz Czira, Theo Tritton, Rosie Wild, Chris Compton, Afisi Ismaila   +7 more
doaj   +1 more source

Clinical utility of ingenol mebutate in the management of actinic keratosis. Perspectives from clinical practice [PDF]

, 2018
Actinic keratoses (AKs) are epidermal cutaneous neoplasia observed predominantly in middle-aged and older subjects with mainly photo type I and photo type II on sun-exposed surfaces as a result of DNA damage.
Bernardini, Nicoletta, Potenza, Concetta, Proietti, Ilaria, Skroza, Nevena   +3 more
core   +1 more source

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Clinical and economic burden of pneumococcal disease in US adults aged 19–64 years with chronic or immunocompromising diseases: an observational database study

BMC Infectious Diseases, 2018
Background Despite the widespread availability of pneumococcal vaccines, rates of pneumococcal disease are disproportionately high in adults with chronic and immunocompromising conditions. This study investigated pneumococcal disease rates and associated
Dongmu Zhang, Tanaz Petigara, Xiaoqin Yang   +2 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Real-world study of patients with locally advanced HNSCC in the community oncology setting

Frontiers in Oncology, 2023
IntroductionThere is a need to understand the current treatment landscape for LA HNSCC in the real-world setting.MethodsThis retrospective study assessed real-world outcomes and treatment patterns of 1,158 adult patients diagnosed with locally advanced ...
Christopher M. Black, Karthik Ramakrishnan, Eric Nadler, Eric Nadler, Wan-Yu Tseng, Chuck Wentworth, John Murphy, Nicole Fulcher, Liya Wang, Melannie Alexander, Gregory Patton   +10 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Evaluating the Effectiveness of 2024–2025 Seasonal mRNA-1273 Vaccination Against COVID-19-Related Hospitalizations and Medically Attended COVID-19 Among Adults Aged ≥ 18 years in the United States: An Observational Matched Cohort Study

Infectious Diseases and Therapy
Introduction This study evaluated the effectiveness of Moderna’s updated mRNA-1273 vaccine targeting the KP.2 variant, compared to people who did not receive any 2024–2025 COVID-19 vaccine, in preventing COVID-19-associated hospitalizations and medically-
Nevena Vicic, Alina Bogdanov, Zhe Zheng, Taylor Ryan, Ni Zeng, Keya Joshi, Tianyi Lu, Machaon Bonafede, Andre B. Araujo, Amanda Wilson   +9 more
doaj   +1 more source

Gender Matters! Analyzing Global Cultural Gender Preferences for Venues Using Social Sensing

, 2017
Gender differences is a phenomenon around the world actively researched by social scientists. Traditionally, the data used to support such studies is manually obtained, often through surveys with volunteers.
Almeida, Jussara M, Loureiro, Antonio A F, Mueller, Willi, Silva, Thiago H   +3 more
core   +1 more source