Results 51 to 60 of about 2,671,764 (310)

Real-world treatment patterns and outcomes among individuals receiving first-line pembrolizumab therapy for recurrent/metastatic head and neck squamous cell carcinoma

Frontiers in Oncology, 2023
BackgroundPembrolizumab, a PD-1 immune checkpoint inhibitor, is approved as first-line (1L) treatment for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) as monotherapy or in combination with platinum and 5-fluorouracil ...
Christopher M. Black, Glenn J. Hanna, Liya Wang, Karthik Ramakrishnan, Daisuke Goto, Vladimir Turzhitsky, Gleicy M. Hair   +6 more
doaj   +1 more source

Real-World Evidence of Omnipod® 5 Automated Insulin Delivery System Use in 69,902 People with Type 1 Diabetes

Diabetes Technology & Therapeutics
Background: The Omnipod® 5 Automated Insulin Delivery System was associated with favorable glycemic outcomes for people with type 1 diabetes (T1D) in two pivotal clinical trials.
Gregory P. Forlenza, D. Desalvo, G. Aleppo, E. Wilmot, Cari Berget, L. Huyett, I. Hadjiyianni, Jose J. Mendez, L. Conroy, T. Ly, J. Sherr   +10 more
semanticscholar   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source

Clinical and economic burden of pneumococcal disease in US adults aged 19–64 years with chronic or immunocompromising diseases: an observational database study

BMC Infectious Diseases, 2018
Background Despite the widespread availability of pneumococcal vaccines, rates of pneumococcal disease are disproportionately high in adults with chronic and immunocompromising conditions. This study investigated pneumococcal disease rates and associated
Dongmu Zhang, Tanaz Petigara, Xiaoqin Yang   +2 more
doaj   +1 more source

Correlation Between Early Time-to-Event Outcomes and Overall Survival in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Receiving Definitive Chemoradiation Therapy: Systematic Review and Meta-Analysis

Frontiers in Oncology, 2022
BackgroundOverall survival (OS) is the most patient-relevant outcome in oncology; however, in early cancers, large sample sizes and extended follow-up durations are needed to detect statistically significant differences in OS between interventions.
Christopher M. Black, Sam Keeping, Ali Mojebi, Karthik Ramakrishnan, Diana Chirovsky, Navneet Upadhyay, Dylan Maciel, Dieter Ayers   +7 more
doaj   +1 more source

Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence.

Journal of Allergy and Clinical Immunology, 2019
The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of
J. Bousquet, H. Schünemann, A. Togias, C. Bachert, M. Erhola, P. Hellings, L. Klimek, O. Pfaar, D. Wallace, I. Ansotegui, I. Agache, A. Bedbrook, K. Bergmann, M. Bewick, P. Bonniaud, S. Bosnic‐Anticevich, I. Bossé, J. Bouchard, L. Boulet, J. Brożek, G. Brusselle, M. Calderón, W. Canonica, L. Caraballo, V. Cardona, T. Casale, L. Cecchi, D. Chu, E. Costa, Á. Cruz, W. Czarlewski, G. D'Amato, P. Devillier, M. Dykewicz, M. Ebisawa, Jean-Louis Fauquert, W. Fokkens, J. Fonseca, J. Fontaine, B. Gemicioğlu, R. V. van Wijk, T. Haahtela, S. Halken, D. Ierodiakonou, Tomohisa Iinuma, J. Ivancevich, M. Jutel, I. Kaidashev, M. Khaitov, O. Kalayci, Jörg Kleine Tebbe, M. Kowalski, P. Kuna, V. Kvedarienė, S. La Grutta, Désirée Larenas‐Linemann, S. Lau, D. Laune, L. Le, P. Lieberman, K. L. Lødrup Carlsen, O. Lourenço, G. Marien, P. Carreiro‐Martins, E. Mélen, E. Menditto, H. Neffen, G. Mercier, Ralph Mosgues, J. Mullol, A. Muraro, L. Namazova, E. Novellino, R. O'Hehir, Y. Okamoto, K. Ohta, Hae‐Sim Park, P. Panzner, G. Passalacqua, N. Pham-Thi, D. Price, G. Roberts, N. Roche, C. Rolland, N. Rosário, D. Ryan, B. Samoliński, M. Sánchez-Borges, G. Scadding, M. Shamji, A. Sheikh, A. T. Bom, S. Toppila-Salmi, Ioana Tsiligianni, M. Valentín-Rostán, A. Valiulis, E. Valovirta, M. Ventura, S. Walker, S. Waserman, A. Yorgancioglu, T. Zuberbier   +101 more
semanticscholar   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

Review of real-world evidence of dual inhibition of VEGF-A and ANG-2 with faricimab in NAMD and DME

International Journal of Retina and Vitreous
Management of vitreoretinal disorders (e.g., neovascular age-related macular degeneration [nAMD] and diabetic macular edema [DME]) have assumed the standard therapy of lifelong anti-VEGF injections with drugs like aflibercept, brolucizumab, ranibizumab ...
Fernando M. Penha, Maliha Masud, Zoha A. Khanani, Mathew J. Thomas, Rodney Fong, Kyler Smith, Avishay Chand, Majid Khan, G. Gahn, G. Melo, A. Khanani   +10 more
semanticscholar   +1 more source

Rationale, Strengths, and Limitations of Real-World Evidence in Oncology: A Canadian Review and Perspective

The Oncologist, 2022
Randomized controlled trials (RCTs) continue to be the basis for essential evidence regarding the efficacy of interventions such as cancer therapies.
L. Azoulay
semanticscholar   +1 more source

Burden of metabolic dysfunction-associated steatohepatitis, with and without metabolic syndrome, obesity, or diabetes

BMC Gastroenterology
Background Metabolic dysfunction-associated steatohepatitis (MASH) is commonly comorbid with metabolic syndrome; however, MASH can occur in the absence of metabolic syndrome.
Elliot B. Tapper, Taylor Ryan, Dave Lewandowski, Jessamine P. Winer-Jones, Machaon Bonafede, Yestle Kim   +5 more
doaj   +1 more source