Results 131 to 140 of about 5,198,783 (315)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Booklet of CGIAR Centre Policy Instruments, Guidelines and Statements on Genetic Resources, Biotechnology and Intellectual Property Rights - Version II [PDF]

, 2003
This booklet contains the common genetic resources related policies of the Future Harvest Centres. These policies have been endorsed for System-wide use by the CGIAR Members, the Genetic Resources Policy Committee (GRPC) and/or the Centre Directors ...
CGIAR Systemwide Genetic Resources Programme, CGIAR Genetic Resources Policy Committee   +1 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia : GENFI results

: INTRODUCTION Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD).
Petr, Jan, Butler, Chris, Masellis, Mario, Rogaeva, Ekaterina, Graff, Caroline, Jiskoot, Lize C., Bocchetta, Martina, Bouzigues, Arabella, Seelaar, Harro, Santana, Isabel, Tartaglia, Maria Carmela, Russell, Lucy L., Laforce, Robert, Synofzik, Matthis, Mitchell, Sara B., Galimberti, Daniela, Freedman, Morris, Genetic Frontotemporal Dementia Initiative (GENFI), Moreno, Fermin, Ducharme, Simon, Sorbi, Sandro, Finger, Elizabeth, Gerhard, Alex, Black, Sandra E., Luciw, Nicholas, Levin, Johannes, van Swieten, John C, Mirza, Saira S., Rowe, James B., de Mendon\ue7a, Alexandre, Otto, Markus, Cash, David, Pasternak, Maurice, Tiraboschi, Pietro, MacIntosh, Bradley J., Sanchez-Valle, Raquel, Tang-Wai, David, Rohrer, Jonathan D., Bruffaerts, Rose, Borroni, Barbara, Strafella, Antonio P., Thomas, David, Mutsaerts, Henri J.M.M., Vandenberghe, Rik   +43 more
core  

Metabolic syndrome in inflammatory bowel disease: Association with genetic markers of obesity and inflammation

, 2019
Metabolic syndrome (MS) and inflammatory bowel disease (IBD) share common pathophysiological features including chronic inflammation in visceral adipose tissue. However, the interplay of these two pathologies is still unraveled.
Stanković, Biljana, Klaassen, Kristel, Dragašević, Sanja, Kotur, Nikola, Pavlović, Sonja, Sržentić Drazilov, Sanja, Popović, Dragan   +6 more
core