Results 231 to 240 of about 7,786,025 (339)

Genetic Diversity and Population Structure in Two Mangrove Species (<i>Sonneratia alba</i> and <i>Sonneratia caseolaris</i>) Across Coastal Areas of Thailand. [PDF]

Biology (Basel)
Khanbo S, Naktang C, Kongkachana W, Yundaeng C, Jomchai N, Narong N, Pravinvongvuthi T, Maprasop P, Promchoo W, Tangphatsornruang S, Pootakham W.   +10 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Age-Related Genetic Causal Association Between Asthma and Delirium: A Bidirectional Two-Sample Mendelian Randomization. [PDF]

Brain Behav
Wang X, Guo G, Liu J.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Genomic Differentiation, Diversity, and Genetic Structuring of <i>Euterpe edulis</i> Mart. Morphotype in Espírito Santo, Brazil. [PDF]

Ecol Evol
Santos JG, de Almeida FAN, Boudet-Fernandes HQ, Dos Santos PHD, Fernandes M, Dos Santos SC, Ferreira A, Ferreira MFDS.   +7 more
europepmc   +1 more source

Geological conditions, genetic mechanisms and accumulation patterns of helium resources

Shizhen Tao, Yiqing YANG, Yue Chen, Xiangbai LIU, Wei Yang, Jian Li, Yiping Wu, Xiaowan Tao, Jianrong Gao, Yanyan CHEN, Xiaobo Wang, Xiaozhi Wu, Xiuyan CHEN, Qian Li, Jinhua Jia   +14 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

High gene flow and lack of genetic structure in the commercially important crab <i>Cancer porteri</i> (Brachyura: Cancridae) along 1,500 km of the Chilean coast revealed by SNP markers. [PDF]

PeerJ
Soto J, Rojas-Hernández N, Vega-Retter C, Pardo LM, Parada Veliz C, Gallardo Salamanca MLÁ, Veliz D.   +6 more
europepmc   +1 more source

Expression of Chemokines in GVHD Target Organs Is Influenced by Conditioning and Genetic Factors and Amplified by GVHR

, 2006
Markus Y. Mapara, Corinna Leng, Yong‐Mi Kim, Roderick T. Bronson, Anna Lokshin, Andrew D. Luster, Megan Sykes   +6 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source