Results 81 to 90 of about 5,198,783 (315)

Semantically Driven Mutation in Genetic Programming [PDF]

, 2008
Using semantic analysis, we present a technique known as semantically driven mutation which can explicitly detect and apply behavioural changes caused by the syntactic changes in programs that result from the mutation operation. Using semantically driven
Beadle, Lawrence, Colin G. Johnson, Johnson, Colin G., Lawrence Beadle   +3 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Management of Hereditary Spastic Paraplegia: A Systematic Review of the Literature

Frontiers in Neurology, 2019
The term hereditary spastic paraplegia (HSP) embraces a clinically and genetically heterogeneous group of neurodegenerative diseases characterized by progressive spasticity and weakness of the lower limbs.
Marta Bellofatto, Giovanna De Michele, Aniello Iovino, Alessandro Filla, Filippo M. Santorelli   +4 more
doaj   +1 more source

Genetics of osteoporosis [PDF]

Current Opinion in Endocrinology and Diabetes, 1995
There is clear evidence of genetic modulation of bone phenotype parameters including bone density, quantitative ultrasound, bone size, and bone turnover. At any particular age and phase of life, genetic factors explain about 70% of the variance in bone phenotype after adjustment for major medical and disease factors.
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Correlation between Genetic and Geographic Structure in Europe [PDF]

, 2008
SummaryUnderstanding the genetic structure of the European population is important, not only from a historical perspective, but also for the appropriate design and interpretation of genetic epidemiological studies.
Becker, C.,, Nurnberg, P.,, Schreiber, S, Uitterlinden, André; id_orcid, Bertranpetit, J., Kayser, M.,, Rivadeneira, F., Palo, J, Tagliabracci, Adriano, Comas, D.,, Wichmann, H.-E., Rüther, A., Lu, TT, Hoimlund, G, Bindoff, L.A.,, Balascakova, M.,, Gether, U., Comas, D., Nelson, Matthew R, Sajantila, Antti, Junge, O., Freitag-Wolf, S.,, Kouvatsi, Anastasia, Kayser, M., Nothnagel, M, Krawczak, M, Parson, W., Gether, Ulrik, Werge, T, Mollet, I.,, Lao Grueso, Oscar, Uitterlinden, André G, Becker, C., Freitag-Wolf, S, Hofman, Bert, Sajantila, A.,, Balascakova, M, Caliebe, Amke, Comas, D, Bindoff, Laurence A, Mollet, I., Gieger, Christian, Parson, W.,, Ruther, A.,, Bindoff, L.A., Schreiber, S.,, Holmlund, G., Hofman, A., Krawczak, M.,, Hofman, A.,, Freitag-Wolf, S., Gieger, C, Bindoff, Laurence A., Uitterlinden, André G., Bertranpetit, Jaume, Uitterlinden, A.G., Werge, Thomas, Palo, J.,, Kayser, Manfred, Wichmann, Heinz-Erich, Lu, T.T., Uitterlinden, André, Macek, Milan, Krawczak, M., Kouvatsi, A, Gether, U, Macek, M, Holmlund, Gunilla,, Becker, C, Nurnberg, P, Mollet, Isabelle, Gieger, C., Werge, T.,, Ploski, Rafal, Caliebe, A., Schreiber, Stefan, Parson, W, Junge, Olaf, Nürnberg, P., Bertranpetit, J.,, Rivadeneira, Fernando, Schreiber, S., Gether, U.,, Nothnagel, M., Caliebe, A, Lu, T.T.,, Ruther, A, Mollet, I, Sajantila, A, Nothnagel, M.,, Palo, Jukka, Nelson, M.R., Lu, Timothy T., Tagliabracci, A.,, Comas, David, Nelson, M.R.,, Lao, Oscar, Wichmann, H.-E.,, Becker, Christian, Lao, O., Ploski, R., Junge, O.,, Nelson, Matthew R., Hofman, Albert, Balascakova, Miroslava, Ploski, R, Macek, M., Wichmann, HE, Kouvatsi, A.,, Lu, Timothy T, Nelson, MR, Parson, Walther, Ploski, R.,, Freitag-Wolf, Sandra, Rivadeneira, F.,, Bindoff, LA, Caliebe, A.,, Kouvatsi, A., Rüther, Andreas, Nürnberg, Peter, Bertranpetit, J, Macek, M.,, Gieger, C.,, Lao, O.,, Junge, O, Holmlund, Gunilla, Tagliabracci, A., Krawczak, Michael, Tagliabracci, A, Sajantila, A., Werge, T., Uitterlinden, A.G.,, Balascakova, M., Palo, J., Nothnagel, Michael   +134 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Interactions of genetic and environmetal factors in chronic obstructive pulmonary disease

, 2019
Chronic obstructive pulmonary disease (COPD) is featured by abnormal inflammatory response of the lungs to toxic particles or gases, such as cigarette smoke.
Stanković, Marija, Dragica, Radojković
core  

Prodromal language impairment in genetic frontotemporal dementia within the GENFI cohort

, 2023
: OBJECTIVE To identify whether language impairment exists presymptomatically in genetic frontotemporal dementia (FTD), and if so, the key differences between the main genetic mutation groups.
Rademakers, Rosa, Masellis, Mario, Graff, Caroline, Bocchetta, Martina, Bouzigues, Arabella, Seelaar, Harro, Santana, Isabel, Tartaglia, Maria Carmela, Butler, Chris R., Convery, Rhian S., Le Ber, Isabelle, Greaves, Caroline V., Russell, Lucy L., Genetic FTD Initiative (GENFI), Laforce, Robert, Synofzik, Matthis, Galimberti, Daniela, Moreno, Fermin, Ducharme, Simon, Sorbi, Sandro, Finger, Elizabeth, Gerhard, Alex, Pasquier, Florence, Cash, David M., Levin, Johannes, MacDougall, Amy M., Rowe, James B., de Mendon\ue7a, Alexandre, Otto, Markus, Tiraboschi, Pietro, Samra, Kiran, Jiskoot, Lize, Sanchez-Valle, Raquel, Rohrer, Jonathan D., Bruffaerts, Rose, Borroni, Barbara, van Swieten, John C., Vandenberghe, Rik   +37 more
core  

On the origin of the mitochondrial genetic code: Towards a unified mathematical framework for the management of genetic information [PDF]

, 2012
The origin of the genetic code represents one of the most challenging problems in molecular evolution. The genetic code is an important universal feature of extant organisms and indicates a common ancestry of different forms of life on earth.
Diego Luis Gonzalez, Rodolfo Rosa, Giannerini, Simone, Simone Giannerini, Gonzalez, Diego Luis, Rosa, Rodolfo   +5 more
core   +1 more source