Results 211 to 220 of about 339,146 (264)
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
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FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
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Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
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The Genetics of Adaptation: A Reassessment
The American Naturalist, 1992We review both the theory and the data supporting the neo-Darwinian claim that adaptation results from the accumulation of many alleles of small effect. The theory supporting this "micromutationist" view is inconclusive. Furthermore, the evidence from genetic analysis is mixed: although some adaptations are apparently based on many genes of small ...
H A, Orr, J A, Coyne
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Individualized self-adaptive genetic operators with adaptive selection in Genetic Programming
2013 World Congress on Nature and Biologically Inspired Computing, 2013In this paper we investigate a new method for improving generalization performance of Genetic Programming(GP) on Binary Classification tasks. The scheme of self adaptive, individualized genetic operators combined with adaptive tournament size is designed to provide balanced, self-adaptive exploration and exploitation.
Jeannie Fitzgerald, Conor Ryan
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Adapting genetic regulatory models by genetic programming
Biosystems, 2004In this paper, we focus on the task of adapting genetic regulatory models based on gene expression data from microarrays. Our approach aims at automatic revision of qualitative regulatory models to improve their fit to expression data. We describe a type of regulatory model designed for this purpose, a method for predicting the quality of such models ...
R, Eriksson, B, Olsson
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Allen Orr and the genetics of adaptation
Evolution, 2021Over most of the 20th century, evolutionary biologists predominantly subscribed to a strong form of "micro-mutationism," in which adaptive phenotypic divergence arises from allele frequency changes at many loci, each with a small effect on the phenotype.
Tim Connallon, Kathryn A. Hodgins
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Adaptive mutation in genetic algorithms
Soft Computing, 2000In Genetic Algorithms mutation probability is usually assigned a constant value, therefore all chromosome have the same likelihood of mutation irrespective of their fitness. It is shown in this paper that making mutation a function of fitness produces a more efficient search.
MARSILI LIBELLI, STEFANO, P. Alba
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