Results 261 to 270 of about 232,851 (305)
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Nature Reviews Gastroenterology & Hepatology, 2014
IBD is a spectrum of chronic disorders that constitute an important health problem worldwide. The hunt for genetic determinants of disease onset and course has culminated in the Immunochip project, which has identified >160 loci containing IBD susceptibility genes.
Van Limbergen, Johan +2 more
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IBD is a spectrum of chronic disorders that constitute an important health problem worldwide. The hunt for genetic determinants of disease onset and course has culminated in the Immunochip project, which has identified >160 loci containing IBD susceptibility genes.
Van Limbergen, Johan +2 more
openaire +5 more sources
2021
While asthma has a strong genetic component, our current ability to systematically understand and predict asthma risk remains low, despite over a hundred genetic associations. The reasons for this unfilled gap range from technical limitations of current approaches to fundamental deficiencies in the way we understand asthma.
Mayank, Bansal +2 more
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While asthma has a strong genetic component, our current ability to systematically understand and predict asthma risk remains low, despite over a hundred genetic associations. The reasons for this unfilled gap range from technical limitations of current approaches to fundamental deficiencies in the way we understand asthma.
Mayank, Bansal +2 more
openaire +2 more sources
Annual Review of Genomics and Human Genetics, 2005
▪ Abstract  Chemical genetics is an emerging approach for studying biological systems using chemical tools. This strategy aims to reveal the macromolecules responsible for regulating biological systems; thus, the approach shares much in common with genetics.
Inese, Smukste, Brent R, Stockwell
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▪ Abstract  Chemical genetics is an emerging approach for studying biological systems using chemical tools. This strategy aims to reveal the macromolecules responsible for regulating biological systems; thus, the approach shares much in common with genetics.
Inese, Smukste, Brent R, Stockwell
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Advances in molecular genetics
The American Journal of Surgery, 1997The three known mechanisms of cellular transformation and oncogenesis include mutations in proto-oncogenes, inactivation of both copies of a tumor suppressor gene, and defects in DNA mismatch repair genes. Examples of each are included to substantiate the importance of understanding these mechanisms.
T C, Lairmore, J A, Norton
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Advances in the genetics of sarcoidosis
Clinical Genetics, 2008Sarcoidosis is an uncommon disease of granulomatous inflammation. Genetic predisposition to sarcoidosis is indicated by observations of familial clustering, increased concordance in monozygotic twins over other siblings, and variations in susceptibility and disease presentation among different ethnic groups.
G, Smith +3 more
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Advances in Genetics in Dermatology
1982The spectacular growth of cellular and molecular biology in the past two decades has led to important advances in our understanding of many diseases. This also has been true for disorders of the skin, most particularly those with a clear genetic basis.
H P, Baden, P A, Hooker
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Canadian Journal of Genetics and Cytology, 1975
Although advances in medical genetics are designed ultimately to help human beings receive better health care, they pose many problems for society. Some of these concerns are real, but others result from misunderstanding and/or misrepresentation of the true implication of certain developments in genetics.
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Although advances in medical genetics are designed ultimately to help human beings receive better health care, they pose many problems for society. Some of these concerns are real, but others result from misunderstanding and/or misrepresentation of the true implication of certain developments in genetics.
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Current Opinion in Rheumatology, 2013
The purpose of this review is to highlight recent progress in defining the effects of variation in the germline DNA sequence on the susceptibility to systemic lupus erythematosus.The genetic contributions to lupus susceptibility have been increasingly defined in recent years, although a large proportion of the genetic heritability of this disease ...
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The purpose of this review is to highlight recent progress in defining the effects of variation in the germline DNA sequence on the susceptibility to systemic lupus erythematosus.The genetic contributions to lupus susceptibility have been increasingly defined in recent years, although a large proportion of the genetic heritability of this disease ...
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Recent advances in the genetics of sarcoidosis
Journal of Medical Genetics, 2013Sarcoidosis is a heterogeneous inflammatory disorder of unknown origin that may affect virtually any organ, although intrathoracic engagement is almost universal. Sarcoidosis may present rather dramatically as an acute disease, which usually resolves either spontaneously or with treatment, while other patients have an insidious onset and a chronic ...
SPAGNOLO, Paolo, Grunewald J.
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