Results 61 to 70 of about 625,169 (309)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

A Path to Implement Precision Child Health Cardiovascular Medicine. [PDF]

open access: yes, 2017
Congenital heart defects (CHDs) affect approximately 1% of live births and are a major source of childhood morbidity and mortality even in countries with advanced healthcare systems. Along with phenotypic heterogeneity, the underlying etiology of CHDs is
Brian Reemtsen   +8 more
core   +2 more sources

Genetic variability analysis in diverse maize genotypes (Zea mays L.) [PDF]

open access: yesElectronic Journal of Plant Breeding, 2014
The present study was carried out to assess the genetic variability, heritability, genetic advance for yield and kernel quality traits in twenty diverse maize genotypes.
Radheshyam Sharma, S. R. Maloo and Arunabh Joshi
doaj  

Using genotyping-by-sequencing to understand Musa diversity : [P449] [PDF]

open access: yes, 2014
This project is part of a larger effort to apply genomics technologies to assess genetic diversity and to advance genetic improvement efforts in Musa (banana and plantain), a major staple food crop in the developing world.
Chan, Agnes P.   +6 more
core  

Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo. [PDF]

open access: yes, 2014
Staphylococcus aureus is a commensal and major pathogen of humans and animals. Comparative genomics of S. aureus populations suggests that colonization of different host species is associated with carriage of mobile genetic elements (MGE), particularly ...
Gould, KA   +5 more
core   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Variability studies for yield and its contributing traits in okra [PDF]

open access: yesElectronic Journal of Plant Breeding, 2010
Twelve okra genotypes were crossed in diallel fashion excluding reciprocals to generate 66 one-way hybrids. All the F1’s along with their parentswere grown at Vegetable Research Farm of the Department of Vegetable Crops, Punjab Agricultural University ...
Salesh Kumar Jindal, Deepak Arora and T R Ghai
doaj  

Genetic advances in dermatophytes. [PDF]

open access: yesFEMS microbiology letters, 2011
Millions of superficial fungal infections are annually observed in humans and animals. The majority of these mycoses are caused by dermatophytes, a specialized group of filamentous fungi that exclusively infect keratinized host structures. Despite the high prevalence of the disease, dermatophytosis, little is known about the pathogenicity mechanisms of
Grumbt, Maria   +2 more
openaire   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Integrating Evolutionary Computation with Neural Networks [PDF]

open access: yes, 1995
There is a tremendous interest in the development of the evolutionary computation techniques as they are well suited to deal with optimization of functions containing a large number of variables.
Hibbs, R.A.   +3 more
core   +4 more sources

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