Results 111 to 120 of about 8,428,042 (339)

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Computational Complexity Analysis of Simple Genetic Programming On Two Problems Modeling Isolated Program Semantics [PDF]

arXiv, 2010
Analyzing the computational complexity of evolutionary algorithms for binary search spaces has significantly increased their theoretical understanding. With this paper, we start the computational complexity analysis of genetic programming. We set up several simplified genetic programming algorithms and analyze them on two separable model problems ...
arxiv  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Genetic Algorithm-based Robot Path Planning [PDF]

, 2009
Nowadays, building an intelligent robot that able to move by itself from one location to another without collides with other obstacles is of interest in many applications. In the real world, condition of an environment is always unpredictable and changes
Ibrahim, Mohd Faisal
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

A Comparison between Memetic algorithm and Genetic algorithm for the cryptanalysis of Simplified Data Encryption Standard algorithm [PDF]

International Journal of Network Security & Its Applications 1.1 (2009) 34-42, 2010
Genetic algorithms are a population-based Meta heuristics. They have been successfully applied to many optimization problems. However, premature convergence is an inherent characteristic of such classical genetic algorithms that makes them incapable of searching numerous solutions of the problem domain.
arxiv  

A genetic algorithm for the mixed flow shop problem [PDF]

, 2019
In this thesis we present a new interesting version of the mixed flow shop se-quencing problem, which at the same time is a version of the classic flow shop,a very common topic on operations research.We propose a genetic algorithm to solve it that we ...
Pascual Poch, Mario
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Optimization method of truss structure size and shape based on harmonic search genetic algorithm

Jixie qiangdu
In order to improve the traditional design concept and the lack of optimization of genetic algorithm, and promote the development and innovation of the shape optimization of truss structure, according to the basic principles of harmony search algorithm ...
XIE Jun, ZHANG Huashuai, LIN Shuqin, PANG Bolei, YAN Jie   +4 more
doaj  

An Improved NSGA-III Algorithm Using Genetic K-Means Clustering Algorithm

IEEE Access, 2019
The non-dominated sorting genetic algorithm III (NSGA-III) has recently been proposed to solve many-objective optimization problems (MaOPs). While this algorithm achieves good diversity, its convergence is unsatisfactory.
Qingguo Liu, Xinxue Liu, Jian Wu, Yaxiong Li   +3 more
doaj   +1 more source