Results 21 to 30 of about 527,936 (311)

A node selection algorithm with a genetic method based on PBFT in consortium blockchains

open access: yesComplex & Intelligent Systems, 2022
Industry and research communities have widely studied Blockchain technology, and the consortium blockchain is currently the most used category with a wide range of applications.
Jinyu Zhang   +3 more
doaj   +1 more source

Parallel Genetic Algorithms’ Implementation Using a Scalable Concurrent Operation in Python

open access: yesSensors, 2022
This paper presents an implementation of the parallelization of genetic algorithms. Three models of parallelized genetic algorithms are presented, namely the Master–Slave genetic algorithm, the Coarse-Grained genetic algorithm, and the Fine-Grained ...
Vladislav Skorpil, Vaclav Oujezsky
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Swarming genetic algorithm: A nested fully coupled hybrid of genetic algorithm and particle swarm optimization.

open access: yesPLoS ONE, 2022
Particle swarm optimization and genetic algorithms are two classes of popular heuristic algorithms that are frequently used for solving complex multi-dimensional mathematical optimization problems, each one with its one advantages and shortcomings ...
Panagiotis Aivaliotis-Apostolopoulos   +1 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Intelligent Test Paper Generation with Genetic Algorithm

open access: yesGazi Üniversitesi Fen Bilimleri Dergisi, 2017
In this study, the solution of the problem of generating an intelligent test paper with a genetic algorithm is presented depending on the required criteria in a question bank.
Ufuk TÜL, Adem TUNCER
doaj   +1 more source

New Genetic Operators for Developing S-Boxes With Low Boomerang Uniformity

open access: yesIEEE Access, 2022
The boomerang uniformity measures the resistance of block ciphers to boomerang attacks and has become an essential criterion of the substitution box (S-box).
Man Kang, Mingsheng Wang
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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