Results 121 to 130 of about 8,825,337 (378)

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

The causal impact of smoking behavior on osteoarthritis: a Mendelian randomization analysis

Frontiers in Public Health
ObjectiveAlthough smoking and osteoarthritis (OA) have been linked in a number of studies, the exact cause of the association is still unknown and the conclusion is controversial. The purpose of this study was to use Mendelian randomization (MR) analysis
Qiang Xiao, Susu Dong, Yafen Tan, Xuan Zhang, Lu Yao, Qiuping Li, Tianli Wang   +6 more
doaj   +1 more source

Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies [PDF]

, 2019
Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette’s syndrome and other tic disorders. The authors conducted
Gilles de la Tourette GWAS Replication Initiative, Psychiatric Genomics Consortium Tourette Syndrome Working Group, Tourette Association of America International Consortium for Genetics, Tourette International Collaborative Genetics Study, Woods, Douglas W.   +4 more
core   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Immune-checkpoint HLA-G gene polymorphisms, 3’-UTR types and their association with hepatocellular carcinoma and treatment response in Indian population

Frontiers in Immunology
BackgroundHuman leukocyte antigen-G (HLA-G) is a cancer-associated immune checkpoint protein implicated in tumor-driven immune escape mechanisms. This study was undertaken to determine genetic variations at the 3’-UTR of the HLA-G gene that may alter its
Neeti Nadda, Renu Yadav, Neelanjana Roy, Nita Singh, Sonu Kumar, Shashi Bala Paul, Shivanand Gamanagatti, Anoop Saraya, Shalimar, Baibaswata Nayak   +9 more
doaj   +1 more source

Evaluation of the Association of Htr2a Gene Rs6313 Polymorphism with Heroin Dependence in a Sample from Northwest Iran

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021
Introduction: Heroin dependence is a chronic relapsing disorder caused by a combination of genetic, epigenetic, and environmental factors. The genetic contribution in the vulnerability to heroin dependence is 40%-60%. Alterations in dopamine transport in
Fatemeh Mahmoudi, Leila Mehdizadeh fanid, Narges Zeinalzadeh, Mohammad ali Hosseinpour feizy   +3 more
doaj  

HARDY-WEINBERG EQUILIBRIUM ASSUMPTIONS IN CASE-CONTROL TESTS OF GENETIC ASSOCIATION [PDF]

, 2009
The case-control study design is commonly used in genetic association study with a binary trait using unrelated individuals from a population. To test association with a binary trait in a case-control or cohort study, the standard analysis is a chi ...
Lee, Myoungkeun
core  

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

5-HTR1A and 5-HTR2A genetic polymorphisms and SSRI antidepressant response in depressive Chinese patients

Neuropsychiatric Disease and Treatment, 2016
Zai-Quan Dong,1,* Xi-Rong Li,2,* Lin He,3,4 Guang He,3,4 Tao Yu,3,4 Xue-Li Sun1 1Psychological Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 2Mental Health Center, First Affiliated Hospital, Chongqing Medical University, Chongqing ...
Dong Z, Li X, He L, He G, Yu T, Sun X
doaj  

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source