Results 141 to 150 of about 226,034 (265)

Interaction between MARK3 (rs11623869), PLCB4 (rs6086746) and GEMIN2 (rs2277458) variants with bone mineral density and serum 25-hidroxivitamin D levels in Mexican Mestizo women

Frontiers in Endocrinology
IntroductionUnderstanding the genetic factors contributing to variations in bone mineral density (BMD) and vitamin D could provide valuable insights into the pathogenesis of osteoporosis.
Diana I. Aparicio-Bautista, Rogelio F. Jiménez-Ortega, Rogelio F. Jiménez-Ortega, Adriana Becerra-Cervera, Adriana Becerra-Cervera, Arnoldo Aquino-Gálvez, Valeria Ponce de León-Suárez, Leonora Casas-Ávila, Jorge Salmerón, Alberto Hidalgo-Bravo, Berenice Rivera-Paredez, Rafael Velázquez-Cruz   +11 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Feasibility of SNP Genotyping Using Dried Blood Spot Samples Collected in an Epidemiological Study and Its Integration With Genetic Risk Analysis for Endometriosis

Reproductive Medicine and Biology
Purpose This study evaluated the feasibility of single‐nucleotide polymorphism (SNP) genotyping using dried blood spot (DBS) samples stored under various conditions, based on the genotyping success rate and concordance with whole blood results.
Yoshikazu Kitahara, Yuki Ideno, Kensaku Tomiyoshi, Yoko Onizuka, Kazue Nagai, Akira Iwase, Junko Shimada, Hiroshi Ohnishi, Kunihiko Hayashi   +8 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Methylenetetrahydrofolate Reductase Gene Variants Confer Potential Vulnerability to Autism Spectrum Disorder in a Saudi Community

Neuropsychiatric Disease and Treatment, 2019
Arwa H Arab,1 Nasser A Elhawary2,3 1Department of Psychology, Faculty of Arts and Humanities, King Abdul-Aziz University, Jeddah 21589, Saudi Arabia; 2Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Mecca 21955, Saudi Arabia;
Arab AH, Elhawary NA
doaj  

Betting Odds and Genetic Associations [PDF]

JNCI Journal of the National Cancer Institute, 2004
Duncan C, Thomas, David G, Clayton
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Comparative methods for association studies: a case study on metabolite variation in a Brassica rapa core collection

, 2011
Background Association mapping is a statistical approach combining phenotypic traits and genetic diversity in natural populations with the goal of correlating the variation present at phenotypic and allelic levels.
Paulo, M.J., Maria João Paulo, Pino del Carpio, D., Bonnema Guusje, Dunia Pino Del Carpio, Paulo Maria João, De Vos Ric C. H., Maliepaard Chris, Bonnema, A.B., Vos, C.H., de, Chris Maliepaard, de Vos, C.H., Basnet Ram Kumar, Ric C. H. De Vos, Guusje Bonnema, Ric C H De Vos, Basnet, R.K., Ram Kumar Basnet, Maliepaard, C.A., Pino Del Carpio Dunia   +19 more
core   +1 more source

Association studies in psychiatric genetics [PDF]

Molecular Psychiatry, 1997
M J, Owen, P, Holmans, P, McGuffin
openaire   +2 more sources

Genetic associations with educational fields

Nature Genetics
Abstract Educational field choices shape careers, wellbeing and the societal skill distribution, yet genetic influences on what people study remain poorly understood. Here we show that genetic factors are associated with educational field specializations using genome-wide association studies (GWASs) across 463,134
Rosa Cheesman, Ville Anapaz, Sjoerd van Alten, Abdel Abdellaoui, Ralph Porneso, Joakim C. Ebeltoft, Ziada Ayorech, Perline A. Demange, Espen Moen Eilertsen, Agnes Fauske, Alexandra Havdahl, Hannu Lahtinen, Torkild Hovde Lyngstad, Qi Qin, Andrea Ganna, Eivind Ystrom   +15 more
openaire   +3 more sources