Results 121 to 130 of about 226,034 (265)

Effective Sample Size: Quick Estimation of the Effect of Related Samples in Genetic Case-Control Association Analyses

, 2007
Correlated samples have been frequently avoided in case-control genetic association studies in part because the methods for handling them are either not easily implemented or not widely known.
Daniel Kastner, Peter K. Gregersen, Wentian F. Li, Yaning B. Yang, Chukwuma Ogunwole, Elaine L. Remmers   +5 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Fine-Mapping the HOXB Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer [PDF]

, 2014
The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the HOXB genetic locus at 17q21 and ...
Schumacher, Fredrick, Elio Riboli (23604), Elaine A. Ostrander (145833), Adam S. Kibel, Ken Muir (523069), Jenny L. Donovan (194899), Koveela Govindasami (523065), Brian E. Henderson (89923), Peter Kraft, Ruth C. Travis, Muir, Ken, Manuel R Teixeira, Jong Y. Park, Janet L Stanford, Hamdy, Freddie C., Schaid, Daniel, Kraft, Phillip, Børge G. Nordestgaard (89871), Guy, Michelle, Clements, Judith A., Hunter, David, Brian E Henderson, Ken Muir, Elaine A. Ostrander, Lisa B Signorello, Ingles, Sue A., Giles, Graham G., Berndt, Sonja I., Thibodeau, Stephen N., Daniel Schaid, Rosemary A. Wilkinson, Brian E. Henderson, Gapstur, Susan, Park, Jong Y., David E. Neal, Stanford, Janet L., Kaneva, Radka, The UK ProtecT Study Collaborators, Federico Canzian, Ostrander, Elaine A., Wilkinson, Rosemary A., Haiman, Christopher A., David J Hunter, Lisa Cannon Albright, Key, Tim J., Emma J. Sawyer (523067), Borge G. Nordestgaard, Sara Benlloch, Jong Y Park, Stephen Chanock (23589), Nordestgaard, Børge G., Christopher A Haiman, Douglas F. Easton, Christos Mikropoulos (523063), Fredrik Wiklund (372507), Kay-Tee Khaw, Donovan, Jenny, Esther M John, Jianfeng Xu (80211), Ruth C Travis, The UK Genetic Prostate Cancer Study Collaborators, Freddie C. Hamdy (184070), Neal, David E., Emma J Sawyer, John, Esther M., Stephen N Thibodeau, Albanes, Demetrius, Jugurnauth-Little, Sarah, Lisa B. Signorello (191256), Ruth C. Travis (229120), Govindasami, Koveela, Stephen N. Thibodeau, Riboli, Elio, Sarah Jugurnauth-Little, Lisa Cannon-Albright, Markus Aly, Zsofia Kote-Jarai (69444), Sonja I. Berndt (202053), David E Neal, Judith A. Clements, UK Genetic Prostate Cancer Study Collaborators, Christos Mikropoulos, Batra, Jyotsna, Campa, Daniele, Henrik Gronberg (3452111), Cezary Cybulski (196608), Signorello, Lisa B., Muir, Kenneth, Chee Goh, Sara Benlloch (523055), Adam S Kibel, Sarah Jugurnauth-Little (523054), Fredrick Schumacher (163014), Markus Aly (523056), Sonja I. Berndt, Xu, Jianfeng, Maren Weischer, Michelle Guy, Edward J. Saunders, Rosalind A. Eeles (194860), Gronberg, Henrik, Jenny L. Donovan, Stephen N. Thibodeau (163051), Sue A. Ingles (202076), Janet L. Stanford (202132), Jyotsna Batra (138092), Pharoah, Paul, Hunter, David J., Chanock, Stephen, Jyotsna Batra, Børge G Nordestgaard, COGS CRUK GWAS ELLIPSE Initiative, Susan Gapstur, Peter Kraft (15118), Judith A. Clements (138096), Michelle Guy (194876), The PRACTICAL Consortium, Sarah Jugurnauth Little, Adam S. Kibel (523060), Demetrius Albanes, Jianfeng Xu, Cybulski, Cezary, Weischer, Maren, Daniele Campa, Judith A Clements, Maren Weischer (523058), Sara Lindstrom, Tokhir Dadaev (5657926), Cannon-Albright, Lisa, Travis, Ruth C., Hermann Brenner, Kibel, Adam S., Khaw, Kay-Tee, Teixeira, Manuel R., Jenny L Donovan, Fredrick Schumacher, Angela Morgan, Rosalind A Eeles, Andriole, Gerald, Chee Goh (523064), Benlloch, Sara, Stephen Chanock, Richard B. Hayes, Edward J Saunders, Christopher A. Haiman (89922), Schleutker, Johanna, Donovan, Jenny L., Kay Tee Khaw, Elaine A Ostrander, Kraft, Peter, Daniel Schaid (523059), Angela Morgan (523068), Christopher A. Haiman, Kay-Tee Khaw (110271), Lisa B. Signorello, Canzian, Federico, Christiane Maier, Elio Riboli, Sue A. Ingles, Johanna Schleutker (200707), Richard B. Hayes (108159), Tim J Key, Tim J. Key, Sue A Ingles, Severi, Gianluca, Koveela Govindasami, Henderson, Brian E., Hermann Brenner (63649), Graham G. Giles, Esther M. John, Emma J. Sawyer, Morgan, Angela, Graham G Giles, PRACTICAL Consortium, Rosemary A Wilkinson, Paul Pharoah, Daniel A. Leongamornlert (523053), Rosalind A. Eeles, Demetrius Albanes (23581), Jong Y. Park (397964), Sawyer, Emma J., Kote-Jarai, Zsofia, Sara Lindstrom (5648446), Edward J. Saunders (523052), Goh, Chee L., Graham G. Giles (89916), Christiane Maier (328509), Malgorzata Tymrakiewicz, Lisa Cannon-Albright (523061), Freddie C. Hamdy, Henrik Gronberg, Freddie C Hamdy, Janet L. Stanford, Cezary Cybulski, Saunders, Edward J., Ali Amin Al Olama, Douglas F. Easton (89956), Maier, Christiane, Johanna Schleutker, Aly, Markus, Easton, Douglas F., Dadaev, Tokhir, Goh, Chee, Tymrakiewicz, Malgorzata, David E. Neal (6580), Wiklund, Fredrik, Tim J. Key (195511), Rosemary A. Wilkinson (523066), UK ProtecT Study Collaborators, Tokhir Dadaev, Radka Kaneva, Al Olama, Ali Amin, David J. Hunter (50227), Radka Kaneva (523062), Manuel R. Teixeira, Gianluca Severi (89918), Daniele Campa (102616), Daniel A. Leongamornlert, David J. Hunter, Fredrik Wiklund, COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative, Douglas F Easton, Malgorzata Tymrakiewicz (239912), Susan Gapstur (523057), Manuel R. Teixeira (118886), Hayes, Richard B., Zsofia Kote Jarai, Daniel A Leongamornlert, Lindstrom, Sara, Zsofia Kote-Jarai, Gerald Andriole (229131), Gerald Andriole, Leongamornlert, Daniel A., Mikropoulos, Christos, Richard B Hayes, Ali Amin Al Olama (194868), Brenner, Hermann, Esther M. John (107266), Federico Canzian (23588), Gianluca Severi, Paul Pharoah (15105), Eeles, Rosalind A., Sonja I Berndt   +242 more
core   +1 more source

The Journal of heredity

v.
American Genetic Association.
core   +2 more sources

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women

Cancer Medicine, 2019
An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA).
Delores J. Grant, Ani Manichaikul, Anthony J. Alberg, Elisa V. Bandera, Jill Barnholtz‐Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Patricia G. Moorman, Lauren C. Peres, Edward S. Peters, Ann G. Schwartz, Paul D. Terry, Xin‐Qun Wang, Temitope O. Keku, Cathrine Hoyo, Andrew Berchuck, Dale P. Sandler, Jack A. Taylor, Katie M. O’Brien, Digna R. Velez Edwards, Todd L. Edwards, Alicia Beeghly‐Fadiel, Nicolas Wentzensen, Celeste Leigh Pearce, Anna H. Wu, Alice S. Whittemore, Valerie McGuire, Weiva Sieh, Joseph H. Rothstein, Francesmary Modugno, Roberta Ness, Kirsten Moysich, Mary Anne Rossing, Jennifer A. Doherty, Thomas A. Sellers, Jennifer B. Permuth‐Way, Alvaro N. Monteiro, Douglas A. Levine, Veronica Wendy Setiawan, Christopher A. Haiman, Loic LeMarchand, Lynne R. Wilkens, Beth Y. Karlan, Usha Menon, Susan Ramus, Simon Gayther, Aleksandra Gentry‐Maharaj, Kathryn L. Terry, Daniel W. Cramer, Ellen L. Goode, Melissa C. Larson, Scott H. Kaufmann, Rikki Cannioto, Kunle Odunsi, John L. Etter, Ruea‐Yea Huang, Marcus Q. Bernardini, Alicia A. Tone, Taymaa May, Marc T. Goodman, Pamela J. Thompson, Michael E. Carney, Shelley S. Tworoger, Elizabeth M. Poole, Diether Lambrechts, Ignace Vergote, Adriaan Vanderstichele, Els Van Nieuwenhuysen, Hoda Anton‐Culver, Argyrios Ziogas, James D. Brenton, Line Bjorge, Helga B. Salvensen, Lambertus A. Kiemeney, Leon F. A. G. Massuger, Tanja Pejovic, Amanda Bruegl, Melissa Moffitt, Linda Cook, Nhu D. Le, Angela Brooks‐Wilson, Linda E. Kelemen, Paul D.P. Pharoah, Honglin Song, Ian Campbell, Diana Eccles, Anna DeFazio, Catherine J. Kennedy, Joellen M. Schildkraut   +89 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Ankylosing spondylitis and sarcoidosis — Coincidence or association? [PDF]

, 1992
We report a 25-year-old woman presenting with sarcoidosis and bilateral sacroiliitis. Her sarcoidosis related symptoms (malaise, cough and dyspnoea) improved dramatically under treatment with steroids but severe back pain persisted.
Stucki, Gerold, Speich, R., Michel, B. A., Felten, A. von   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source