Results 151 to 160 of about 11,195,425 (262)

Genetic Association Studies in Hepatocellular Carcinoma: Systematic Meta-Analyses, a Comprehensive Field Synopsis, and Epidemiological Evidence. [PDF]

MedComm (2020)
Shi Y, Huang B, Liu X, Liu Y, Hu Q, Lei T, Tang L, Xiao G, Ning T, Yue S, He J, Du Q, Li X, Zhou Y, Zhang Q, Qi C, Ren H, Ren HG.   +17 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Genetic Association Between BTN3A1 Polymorphisms and the Risk of Rheumatoid Arthritis in a Chinese Population. [PDF]

Int J Rheum Dis
Shu Q, Huang A, He C.
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Proceedings of the Joint Conference of the American Library Association - Canadian Library Association

, 1960
The joint conference proceedings from the 1960 American Library Association and Canadian Library Association Conference at Montreal, Quebec, June 19 ...
American Library Association, Canadian Library Association   +1 more
core  

Genetic association meta-analysis is susceptible to confounding by between-study cryptic relatedness. [PDF]

HGG Adv
Tu T, Ochoa A.
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Kernel-smoothed permutation for extreme P-value estimation in genetic association studies. [PDF]

Genetics
Bian J, Wu J, Ethan MacDonald M, Wu L, Long Q, Li C.   +5 more
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Detecting high-order interactions of single nucleotide polymorphisms using genetic programming [PDF]

Motivation: Not individual single nucleotide polymorphisms (SNPs), but high-order interactions of SNPs are assumed to be responsible for complex diseases such as cancer. Therefore, one of the major goals of genetic association studies concerned with such
Schwender, Holger, Ickstadt, Katja, Bernholt, Thorsten, Nunkesser, Robin, Wegener, Ing   +4 more
core