Results 161 to 170 of about 2,782,325 (342)

Genetic Association of Sexual Behavior, Sildenafil, and Hormonal Contraceptives With Mental Disorders. [PDF]

open access: yesCNS Neurosci Ther
Lin Z   +10 more
europepmc   +1 more source

Credible genetic associations?

open access: yesInternational journal of molecular epidemiology and genetics, 2011
The proliferation in genetic association studies, and the recurring failure of initially promising findings to robustly replicate, demonstrates the need for stringent standards to ensure the identification of credible associations. The Human Genome Epidemiology Network has recently published intermin guideliness on evidential criteria for genetic ...
openaire   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Identification of genetic markers associated with milk production traits in Chinese Holstein cattle based on post genome-wide association studies

open access: green, 2019
Zhenwei Yang   +7 more
openalex   +1 more source

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