Results 161 to 170 of about 2,782,325 (342)
Genetic Association of Sexual Behavior, Sildenafil, and Hormonal Contraceptives With Mental Disorders. [PDF]
Lin Z +10 more
europepmc +1 more source
Credible genetic associations?
The proliferation in genetic association studies, and the recurring failure of initially promising findings to robustly replicate, demonstrates the need for stringent standards to ensure the identification of credible associations. The Human Genome Epidemiology Network has recently published intermin guideliness on evidential criteria for genetic ...
openaire +1 more source
Genetic contributions to preterm birth: Implications from epidemiological and genetic association studies [PDF]
Jevon Plunkett, Louis J. Muglia
openalex +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
A rapid review of genetic association studies of parent-of-origin effects and fetal growth. [PDF]
Kang EJW, Dewan AT.
europepmc +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Deep-Neural-Network-Aided Genetic Association Testing in Samples with Related Individuals. [PDF]
Wu X.
europepmc +1 more source

