Results 181 to 190 of about 8,825,337 (378)
Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher +11 morewiley +1 more sourceMulti‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica +10 morewiley +1 more sourceThe power of genetic diversity in genome-wide association studies of lipids
Nature, 2021 S. Graham, S. Clarke, Kuan-Han H. Wu, S. Kanoni, G. Zajac, S. Ramdas, I. Surakka, I. Ntalla, S. Vedantam, T. Winkler, A. Locke, E. Marouli, M. Y. Hwang, Sohee Han, A. Narita, A. Choudhury, A. Bentley, K. Ekoru, A. Verma, B. Trivedi, H. Martin, K. Hunt, Q. Hui, D. Klarin, Xiang Zhu, G. Thorleifsson, A. Helgadóttir, D. Gudbjartsson, H. Hólm, I. Olafsson, M. Akiyama, S. Sakaue, C. Terao, M. Kanai, Wei Zhou, B. Brumpton, Humaira Rasheed, S. Ruotsalainen, A. Havulinna, Y. Veturi, Q. Feng, E. Rosenthal, T. Lingren, J. Pacheco, S. Pendergrass, J. Haessler, F. Giulianini, Y. Bradford, Jason E. Miller, A. Campbell, Kuang Lin, I. Millwood, G. Hindy, A. Rasheed, J. Faul, Wei Zhao, D. Weir, Constance Turman, Hongyan Huang, M. Graff, A. Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, S. Gustafsson, X. Yin, J. Luan, Jinghua Zhao, F. Matsuda, Hye-Mi Jang, Kyungheon Yoon, C. Medina-Gomez, A. Pitsillides, J. Hottenga, G. Willemsen, A. Wood, Y. Ji, Zishan Gao, S. Haworth, R. Mitchell, Jin-Fang Chai, M. Aadahl, Jie Yao, A. Manichaikul, H. Warren, J. Ramírez, J. Bork-Jensen, L. Kårhus, A. Goel, M. Sabater-Lleal, R. Noordam, C. Sidore, E. Fiorillo, Aaron F. McDaid, P. Marques-Vidal, M. Wielscher, S. Trompet, N. Sattar, L. Møllehave, B. Thuesen, M. Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, A. Poveda, A. Kurbasic, C. Lamina, L. Forer, M. Scholz, T. Galesloot, J. Bradfield, E. W. Daw, J. Zmuda, J. Mitchell, C. Fuchsberger, Henry Christensen, J. Brody, M. Feitosa, M. Wojczynski, Michael H. Preuss, M. Mangino, P. Christofidou, N. Verweij, J. Benjamins, J. Engmann, R. Kember, R. Slieker, K. S. Lo, Nuno R Zilhao, P. Le, M. Kleber, G. Delgado, Shaofeng Huo, Daisuke D Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, H. Leonard, J. Marten, B. Schmidt, Marina Arendt, L. Smyth, M. Cañadas-Garre, Chaolong Wang, M. Nakatochi, A. Wong, N. Hutri-Kähönen, X. Sim, Rui Xia, A. Huerta-Chagoya, J. Fernández-López, V. Lyssenko, Meraj Ahmed, A. Jackson, M. Irvin, C. Oldmeadow, Han-Na Kim, S. Ryu, P. Timmers, L. Arbeeva, R. Dorajoo, L. Lange, Xiaoran Chai, Gauri Prasad, L. Lorés-Motta, Marc Pauper, J. Long, Xiaohui Li, E. Theusch, F. Takeuchi, Cassandra N. Spracklen, A. Loukola, S. Bollepalli, S. Warner, Y. X. Wang, W. Wei, T. Nutile, D. Ruggiero, Y. Sung, Y. Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang, K. Kentistou, Mathias Gorski, M. Brumat, K. Meidtner, L. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, E. Hofer, Maoxuan Lin, C. Xue, Jifeng Zhang, M. P. Concas, S. Vaccargiu, Peter J. van der Most, N. Pitkänen, B. Cade, Jiwon Lee, S. W. van der Laan, K. Chitrala, S. Weiss, M. Zimmermann, Jong Young Lee, Hyeok Sun Choi, M. Nethander, S. Freitag-Wolf, L. Southam, N. W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, C. Couture, L. Lyytikäinen, K. Nikus, G. Cuéllar-Partida, H. Vestergaard, Bertha Hildalgo, O. Giannakopoulou, Q. Cai, M. Obura, J. van Setten, Xiaoyin Li, K. Schwander, N. Terzikhan, J. Shin, R. Jackson, A. Reiner, L. Martin, Zhengming Chen, Liming Li, H. Highland, K. Young, T. Kawaguchi, J. Thiery, J. Bis, G. Nadkarni, L. Launer, Huaixing Li, M. Nalls, O. Raitakari, S. Ichihara, S. Wild, C. Nelson, H. Campbell, S. Jäger, T. Nabika, F. Al-Mulla, H. Niinikoski, P. Braund, I. Kolčić, P. Kovacs, Tota Giardoglou, T. Katsuya, K. F. Bhatti, D. D. de Kleijn, G. D. de Borst, E. Kim, H. Adams, M. A. Ikram, Xiaofeng Zhu, F. Asselbergs, A. Kraaijeveld, J. Beulens, X. Shu, L. Rallidis, O. Pedersen, T. Hansen, P. Mitchell, A. Hewitt, M. Kähönen, L. Pérusse, C. Bouchard, A. Tönjes, Y. Chen, C. Pennell, Trevor A. Mori, W. Lieb, A. Franke, C. Ohlsson, D. Mellström, Y. Cho, Hyejin Lee, Jian-Min Yuan, W. Koh, S. Rhee, J. Woo, I. Heid, K. Stark, H. Völzke, G. Homuth, M. Evans, A. Zonderman, O. Polašek, G. Pasterkamp, I. Hoefer, S. Redline, K. Pahkala, A. Oldehinkel, H. Snieder, G. Biino, R. Schmidt, H. Schmidt, Y. E. Chen, S. Bandinelli, G. Dedoussis, T. Thanaraj, S. Kardia, N. Kato, M. Schulze, G. Girotto, B. Jung, C. Böger, Peter K. Joshi, D. Bennett, P. D. De Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris J. Brown, M. Caulfield, P. Munroe, Xiuqing Guo, M. Ciullo, J. Jonas, N. Samani, J. Kaprio, P. Pajukanta, L. Adair, Sonny A Bechayda, H. J. de Silva, A. R. Wickremasinghe, R. Krauss, Jer-Yuarn Wu, W. Zheng, A. D. den Hollander, D. Bharadwaj, A. Correa, James G. Wilson, L. Lind, C. Heng, A. Nelson, Y. Golightly, James F. Wilson, B. Penninx, Hyung-Lae Kim, J. Attia, R. Scott, D. Rao, D. Arnett, M. Walker, H. Koistinen, G. Chandak, C. Yajnik, J. Mercader, Teresa Tusié-Luna, C. Aguilar-Salinas, Clicerio González Villalpando, L. Orozco, M. Fornage, E. Tai, R. V. van Dam, T. Lehtimäki, N. Chaturvedi, Mitsuhiro Yokota, J. Liu, Dermot F. Reilly, A. McKnight, F. Kee, K. Jöckel, M. McCarthy, C. Palmer, V. Vitart, C. Hayward, E. Simonsick, C. V. van Duijn, F. Lu, J. Qu, H. Hishigaki, Xu Lin, W. März, E. Parra, M. Cruz, V. Gudnason, J. Tardif, G. Lettre, L. T. ’t Hart, P. Elders, S. Damrauer, M. Kumari, M. Kivimaki, P. van der Harst, T. Spector, R. Loos, M. Province, B. Psaty, I. Brandslund, P. Pramstaller, K. Christensen, S. Ripatti, E. Widén, H. Hakonarson, S. Grant, L. Kiemeney, J. de Graaf, M. Loeffler, F. Kronenberg, D. Gu, J. Erdmann, H. Schunkert, P. Franks, A. Linneberg, J. Jukema, A. Khera, M. Männikkö, M. Jarvelin, Z. Kutalik, F. Cucca, D. Mook-Kanamori, K. W. van Dijk, H. Watkins, D. Strachan, N. Grarup, P. Sever, N. Poulter, J. Rotter, T. Dantoft, F. Karpe, M. Neville, N. Timpson, Ching-Yu Cheng, T. Wong, C. Khor, C. Sabanayagam, A. Peters, C. Gieger, A. Hattersley, N. Pedersen, P. Magnusson, D. Boomsma, E. D. de Geus, L. Cupples, J. V. van Meurs, M. Ghanbari, P. Gordon-Larsen, Wei Huang, Y. J. Kim, Y. Tabara, N. Wareham, C. Langenberg, E. Zeggini, J. Kuusisto, M. Laakso, E. Ingelsson, G. Abecasis, J. Chambers, J. Kooner, P. D. de Vries, A. Morrison, K. North, M. Daviglus, P. Kraft, N. Martin, J. Whitfield, S. Abbas, D. Saleheen, R. Walters, M. Holmes, C. Black, Blair H. Smith, A. Justice, A. Baras, J. Buring, P. Ridker, D. Chasman, C. Kooperberg, Wei-Qi Wei, G. Jarvik, B. Namjou, M. Hayes, M. Ritchie, P. Jousilahti, V. Salomaa, K. Hveem, B. Åsvold, M. Kubo, Y. Kamatani, Y. Okada, Y. Murakami, U. Thorsteinsdóttir, K. Stefánsson, Y. Ho, J. Lynch, D. Rader, P. Tsao, Kyong‐Mi Chang, Kelly Cho +499 moresemanticscholar +1 more sourceMethylenetetrahydrofolate Reductase Gene Variants Confer Potential Vulnerability to Autism Spectrum Disorder in a Saudi Community
Neuropsychiatric Disease and Treatment, 2019 Arwa H Arab,1 Nasser A Elhawary2,3 1Department of Psychology, Faculty of Arts and Humanities, King Abdul-Aziz University, Jeddah 21589, Saudi Arabia; 2Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Mecca 21955, Saudi Arabia; Arab AH, Elhawary NAdoaj Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam +14 morewiley +1 more sourceInherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
The Lancet, 2016 I. Cleynen, I. Cleynen, G. Boucher, L. Jostins, L. Jostins, L. Jostins, L. P. Schumm, S. Zeissig, T. Ahmad, V. Andersen, J. Andrews, J. Andrews, V. Annese, S. Brand, S. Brant, Judy H. Cho, M. Daly, M. Dubinsky, R. Duerr, L. Ferguson, A. Franke, R. Gearry, R. Gearry, P. Goyette, H. Hakonarson, J. Halfvarson, J. Hov, Hailang Huang, N. Kennedy, L. Kupčinskas, I. Lawrance, James C. Lee, J. Satsangi, S. Schreiber, E. Théâtre, A. V. D. M. Jong, R. Weersma, D. Wilson, D. Wilson, M. Parkes, S. Vermeire, J. Rioux, J. Mansfield, M. Silverberg, G. Radford-Smith, G. Radford-Smith, D. McGovern, J. Barrett, C. Lees +48 moresemanticscholar +1 more source
