Results 181 to 190 of about 8,691,632 (395)

Genetic loci and linkage associations in Neisseria gonorrhoeae and Neisseria meningitidis. [PDF]

, 1989
S E West, V L Clark
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Genetic Association between Dopamine Transporter Protein Alleles and Cocaine-Induced Paranoia [PDF]

, 1995
Joel Gelernter
openalex   +2 more sources

Genetic Parameters, Associations and Path Analysis in Blackgram (Vigna mumgo (L.) Hepper) [PDF]

, 1982
PATEL S.T, SHAH R.M
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Role of Genetic Control and Random Association in Production of Bovine Transferrin Phenotypes

, 1967
H. C. Hines, T.M. Ludwick, W.H. Rausch
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

The Lancet, 2016
I. Cleynen, I. Cleynen, G. Boucher, L. Jostins, L. Jostins, L. Jostins, L. P. Schumm, S. Zeissig, T. Ahmad, V. Andersen, J. Andrews, J. Andrews, V. Annese, S. Brand, S. Brant, Judy H. Cho, M. Daly, M. Dubinsky, R. Duerr, L. Ferguson, A. Franke, R. Gearry, R. Gearry, P. Goyette, H. Hakonarson, J. Halfvarson, J. Hov, Hailang Huang, N. Kennedy, L. Kupčinskas, I. Lawrance, James C. Lee, J. Satsangi, S. Schreiber, E. Théâtre, A. V. D. M. Jong, R. Weersma, D. Wilson, D. Wilson, M. Parkes, S. Vermeire, J. Rioux, J. Mansfield, M. Silverberg, G. Radford-Smith, G. Radford-Smith, D. McGovern, J. Barrett, C. Lees   +48 more
semanticscholar   +1 more source

The power of genetic diversity in genome-wide association studies of lipids

Nature, 2021
S. Graham, S. Clarke, Kuan-Han H. Wu, S. Kanoni, G. Zajac, S. Ramdas, I. Surakka, I. Ntalla, S. Vedantam, T. Winkler, A. Locke, E. Marouli, M. Y. Hwang, Sohee Han, A. Narita, A. Choudhury, A. Bentley, K. Ekoru, A. Verma, B. Trivedi, H. Martin, K. Hunt, Q. Hui, D. Klarin, Xiang Zhu, G. Thorleifsson, A. Helgadóttir, D. Gudbjartsson, H. Hólm, I. Olafsson, M. Akiyama, S. Sakaue, C. Terao, M. Kanai, Wei Zhou, B. Brumpton, H. Rasheed, S. Ruotsalainen, A. Havulinna, Y. Veturi, Q. Feng, E. Rosenthal, T. Lingren, J. Pacheco, S. Pendergrass, J. Haessler, Franco Giulianini, Y. Bradford, Jason E. Miller, A. Campbell, Kuang Lin, I. Millwood, G. Hindy, A. Rasheed, J. Faul, Wei Zhao, D. Weir, Constance Turman, Hongyan Huang, M. Graff, A. Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, S. Gustafsson, X. Yin, J. Luan, Jinghua Zhao, F. Matsuda, Hye-Mi Jang, Kyungheon Yoon, C. Medina-Gomez, A. Pitsillides, J. Hottenga, G. Willemsen, A. Wood, Y. Ji, Zishan Gao, S. Haworth, R. Mitchell, Jin-Fang Chai, M. Aadahl, Jie Yao, A. Manichaikul, H. Warren, J. Ramírez, J. Bork-Jensen, L. Kårhus, A. Goel, M. Sabater-Lleal, R. Noordam, C. Sidore, E. Fiorillo, Aaron F. McDaid, P. Marques-Vidal, M. Wielscher, S. Trompet, N. Sattar, L. Møllehave, B. Thuesen, M. Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, A. Poveda, A. Kurbasic, C. Lamina, L. Forer, M. Scholz, T. Galesloot, J. Bradfield, E. W. Daw, J. Zmuda, J. Mitchell, C. Fuchsberger, Henry Christensen, Jennifer A. Brody, M. Feitosa, M. Wojczynski, Michael H. Preuss, M. Mangino, P. Christofidou, N. Verweij, J. Benjamins, J. Engmann, R. Kember, R. Slieker, K. S. Lo, Nuno R Zilhao, P. Le, M. Kleber, G. Delgado, Shaofeng Huo, Daisuke D Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, H. Leonard, J. Marten, B. Schmidt, Marina Arendt, L. Smyth, M. Cañadas-Garre, Chaolong Wang, M. Nakatochi, A. Wong, N. Hutri-Kähönen, X. Sim, Rui Xia, A. Huerta-Chagoya, J. Fernández-López, V. Lyssenko, Meraj Ahmed, A. Jackson, M. Irvin, C. Oldmeadow, Han-Na Kim, S. Ryu, P. Timmers, L. Arbeeva, R. Dorajoo, L. Lange, Xiaoran Chai, Gauri Prasad, L. Lorés-Motta, Marc Pauper, J. Long, Xiaohui Li, E. Theusch, F. Takeuchi, Cassandra N. Spracklen, A. Loukola, S. Bollepalli, S. Warner, Y. X. Wang, W. Wei, T. Nutile, D. Ruggiero, Y. Sung, Y. Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang, K. Kentistou, Mathias Gorski, M. Brumat, K. Meidtner, L. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, E. Hofer, Maoxuan Lin, C. Xue, Jifeng Zhang, M. P. Concas, S. Vaccargiu, Peter J. van der Most, N. Pitkänen, B. Cade, Jiwon Lee, S. W. van der Laan, K. Chitrala, S. Weiss, M. Zimmermann, Jong Young Lee, Hyeok Sun Choi, M. Nethander, S. Freitag-Wolf, L. Southam, N. W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, C. Couture, L. Lyytikäinen, K. Nikus, G. Cuéllar-Partida, H. Vestergaard, Bertha Hildalgo, O. Giannakopoulou, Q. Cai, M. Obura, J. van Setten, Xiaoyin Li, K. Schwander, N. Terzikhan, J. Shin, R. Jackson, A. Reiner, L. Martin, Zhengming Chen, Liming Li, H. Highland, K. Young, T. Kawaguchi, J. Thiery, J. Bis, G. Nadkarni, L. Launer, Huaixing Li, M. Nalls, O. Raitakari, S. Ichihara, S. Wild, C. Nelson, H. Campbell, S. Jäger, T. Nabika, F. Al-Mulla, H. Niinikoski, P. Braund, I. Kolčić, P. Kovacs, Tota Giardoglou, T. Katsuya, K. F. Bhatti, D. D. de Kleijn, G. D. de Borst, E. Kim, H. Adams, M. A. Ikram, Xiaofeng Zhu, F. Asselbergs, A. Kraaijeveld, J. Beulens, X. Shu, L. Rallidis, O. Pedersen, T. Hansen, P. Mitchell, A. Hewitt, M. Kähönen, L. Pérusse, C. Bouchard, A. Tönjes, Y. Chen, C. Pennell, Trevor A. Mori, W. Lieb, A. Franke, C. Ohlsson, D. Mellström, Y. Cho, Hyejin Lee, Jian-Min Yuan, W. Koh, S. Rhee, J. Woo, I. Heid, K. Stark, H. Völzke, G. Homuth, M. Evans, A. Zonderman, O. Polašek, G. Pasterkamp, I. Hoefer, S. Redline, K. Pahkala, A. Oldehinkel, H. Snieder, G. Biino, R. Schmidt, H. Schmidt, Y. E. Chen, S. Bandinelli, G. Dedoussis, T. Thanaraj, S. Kardia, N. Kato, M. Schulze, G. Girotto, B. Jung, C. Böger, Peter K. Joshi, D. Bennett, P. D. De Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris J. Brown, M. Caulfield, P. Munroe, Xiuqing Guo, M. Ciullo, J. Jonas, N. Samani, J. Kaprio, P. Pajukanta, L. Adair, Sonny A Bechayda, H. J. de Silva, A. R. Wickremasinghe, R. Krauss, Jer-Yuarn Wu, W. Zheng, A. D. den Hollander, D. Bharadwaj, A. Correa, James G. Wilson, L. Lind, C. Heng, A. Nelson, Y. Golightly, James F. Wilson, B. Penninx, Hyung-Lae Kim, J. Attia, R. Scott, D. Rao, D. Arnett, M. Walker, H. Koistinen, G. Chandak, C. Yajnik, J. Mercader, Teresa Tusié-Luna, C. Aguilar-Salinas, Clicerio González Villalpando, L. Orozco, M. Fornage, E. Tai, R. V. van Dam, T. Lehtimäki, N. Chaturvedi, Mitsuhiro Yokota, J. Liu, Dermot F. Reilly, A. McKnight, F. Kee, K. Jöckel, M. McCarthy, C. Palmer, V. Vitart, C. Hayward, E. Simonsick, C. V. van Duijn, F. Lu, J. Qu, H. Hishigaki, Xu Lin, W. März, E. Parra, M. Cruz, V. Gudnason, J. Tardif, G. Lettre, L. T. ’t Hart, P. Elders, S. Damrauer, M. Kumari, M. Kivimaki, P. van der Harst, T. Spector, R. Loos, M. Province, B. Psaty, I. Brandslund, P. Pramstaller, K. Christensen, S. Ripatti, E. Widén, H. Hakonarson, S. Grant, L. Kiemeney, J. de Graaf, M. Loeffler, F. Kronenberg, D. Gu, J. Erdmann, H. Schunkert, P. Franks, A. Linneberg, J. Jukema, A. Khera, M. Männikkö, M. Jarvelin, Z. Kutalik, F. Cucca, D. Mook-Kanamori, K. W. van Dijk, H. Watkins, D. Strachan, N. Grarup, P. Sever, N. Poulter, J. Rotter, T. Dantoft, F. Karpe, M. Neville, N. Timpson, Ching-Yu Cheng, T. Wong, C. Khor, C. Sabanayagam, A. Peters, C. Gieger, A. Hattersley, N. Pedersen, P. Magnusson, D. Boomsma, E. D. de Geus, L. Cupples, J. V. van Meurs, M. Ghanbari, P. Gordon-Larsen, Wei Huang, Y. J. Kim, Y. Tabara, N. Wareham, C. Langenberg, E. Zeggini, J. Kuusisto, M. Laakso, E. Ingelsson, G. Abecasis, J. Chambers, J. Kooner, P. D. de Vries, A. Morrison, K. North, M. Daviglus, P. Kraft, N. Martin, J. Whitfield, S. Abbas, D. Saleheen, R. Walters, M. Holmes, C. Black, Blair H. Smith, A. Justice, A. Baras, J. Buring, P. Ridker, D. Chasman, C. Kooperberg, Wei-Qi Wei, G. Jarvik, B. Namjou, M. Hayes, M. Ritchie, P. Jousilahti, V. Salomaa, K. Hveem, B. Åsvold, M. Kubo, Y. Kamatani, Y. Okada, Y. Murakami, U. Thorsteinsdóttir, K. Stefánsson, Y. Ho, J. Lynch, D. Rader, P. Tsao, Kyong‐Mi Chang, Kelly Cho   +499 more
semanticscholar   +1 more source

Association genetics in barley

, 2012
GWAS in plants feasible, but not for every trait. Very difficult for traits directly related with history of selection, or correlated with population structure. • The choice of germplasm is critical. Core collections are a good starting point, but further elaboration may be needed to achieve an optimum panel.
openaire   +1 more source