Results 221 to 230 of about 7,627,088 (344)

Genetic association analyses of cognitive performance across multi-ancestry older adults: Application of Tobit models. [PDF]

J Alzheimers Dis
Wu X, Tsuchiya I, Aung KZ, Qiao Q, Fardo DW, Nelson PT, Abner EL, James BD, Norris CM, Katsumata Y.   +9 more
europepmc   +1 more source

A comprehensive review of genetic association studies

Genetics in Medicine, 2002
J. Hirschhorn, K. Lohmueller, E. Byrne, K. Hirschhorn   +3 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Genetic association of proinflammatory cytokines in the pathogenesis of frailty syndrome: an application of ordinal logistic regression model. [PDF]

BMC Geriatr
Juárez-Cedillo T, Martínez-Rodríguez N, Rocha-Cruz A, Fragoso JM, Robles-Ramírez RJ, Juárez-Cedillo E.   +5 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Genetic association of lipids characteristics and lipid lowering drug target genes with sepsis. [PDF]

PLoS One
Wang Y, Zhang H, Zhan Y, Li Z, Li S, Zhang Y, Guo S.   +6 more
europepmc   +1 more source

Exploring genetic variability, diversity and trait associations in sunnhemp (Crotolaria juncea L.) accessions for yield improvement

R. Pushpa, Aravindan Shanmugam, R. Arulmozhi, D. Sassikumar, R Suresh, K. Subrahmaniyan   +5 more
openalex   +2 more sources

Genetic associate training program

Academic Medicine, 1978
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Deciphering the Genetic Association Between the FODMAP Diet and Recurring Oral Aphthae-The Mediating Role of Ferroptosis. [PDF]

Food Sci Nutr
Jia B, Wu X, Wang Q, Ren J, Li G, Zheng X, Yang S.   +6 more
europepmc   +1 more source