Results 231 to 240 of about 11,195,425 (262)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

On the analysis of genetic association with long-read sequencing data. [PDF]

PLoS Genet
He G, Scherer SW, Strug LJ.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Genetic Association Study of <i>IL23R</i> and <i>IL12B</i> Polymorphisms with Psoriasis in a Romanian Population. [PDF]

Life (Basel)
Matei-Man AM, Gaal IO, Catana A, Vesa S, Senila S, Candrea E, Orasan M, Puskas A, Man AC, Mocan T.   +9 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Genetic association of NEAT1 gene polymorphism with the progression of colorectal cancer. [PDF]

J Cancer
Shiu BH, Hsieh YH, Huang CC, Tang CH, Chang LC, Su SC, Yang SF.   +6 more
europepmc   +1 more source

GFPT1 as a cross-ancestry validated target for degenerative spinal disease: genetic association in a Chinese cohort and functional characterization in zebrafish. [PDF]

Commun Biol
Yang B, Li F, Zhang Y, Zhang F, Wang Z, Da Y, Yang X, Xing W, Tian J.   +8 more
europepmc   +1 more source

A systematic exploration of gut microbiota-driven blood metabolites in sepsis: an integrated bioinformatics and genetic association study. [PDF]

Front Genet
Zhang Y, Qiu C, Li X, Peng Y, Liu J, Zhu P.   +5 more
europepmc   +1 more source

Advancing drug development for systemic sclerosis by prioritizing findings from human genetic association studies. [PDF]

Rheumatology (Oxford)
Hughes M, McMahan ZH, Assassai S, Denton CP, Providencia R.   +4 more
europepmc   +1 more source