Results 221 to 230 of about 226,034 (265)
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Associative learning and the genetics of schizophrenia
Trends in Neurosciences, 2009Several well-validated susceptibility genes for schizophrenia have now been identified. We suggest that these genes can be divided into two broad classes. Those in the first class have direct effects on synaptic plasticity mediated through actions at glutamatergic synapses; those in the second class impact on meso-limbic dopamine signalling.
Hall, Jeremy +5 more
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Association genetics in crop improvement
Current Opinion in Plant Biology, 2010Increased availability of high throughput genotyping technology together with advances in DNA sequencing and in the development of statistical methodology appropriate for genome-wide association scan mapping in presence of considerable population structure contributed to the increased interest association mapping in plants. While most published studies
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Genetics of ANCA-associated Vasculitides
Current Rheumatology Reports, 2014The distribution of the anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) is not uniform across geographical regions and ethnic and racial groups, suggesting that genetic and environmental factors affect the pathogenesis of these diseases.
Manuel F, Ugarte-Gil, Luis R, Espinoza
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GENETICS OF HLA DISEASE ASSOCIATION
Annual Review of Genetics, 1981INTRODUCTION . THE HLA SYSTEM . .. .. .. ... .. ..... ... ... ... .. ..... ... .. . .... . ... .. ... ... ... .. Genetics of the HLA System . Biology of the HLA System . Structure . Biological junctions .. THE ASSOCIATIONS . MethOds and Findings . Diagnostic and Prognostic Value .
L P, Ryder, A, Svejgaard, J, Dausset
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Association Methods in Human Genetics
2007Genetic association studies are increasingly used in the search for susceptibility variants for human traits. While many of the statistical tools available for such studies are well established, the field is advancing rapidly, as biological and technological developments allow investigators to generate vast amounts of detailed genetic data.
Carl D, Langefeld, Tasha E, Fingerlin
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Genetic associations of high myopia
British Journal of OphthalmologyAims The impact of genetic variants on high myopia (HM) remains unclear. This study aims to systematically evaluate the relationship between genetic polymorphisms and HM. Methods Eligible studies were retrieved from five databases ...
Bin Mao +5 more
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Genetic association studies in cardiology
American Heart Journal, 2005The last decade has witnessed the emergence of the genetic association study into the mainstream clinical literature. Technological advances and the Human Genome Project have resulted in widespread interest in exploring these new variables in clinical disease.
Mark P, Donahue, Andrew S, Allen
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The Genetics of Adeno-Associated Virus
1984Adeno-associated virus (AAV) is a defective parvovirus which is absolutely dependent on coinfection with a helper virus for a productive lytic cycle (for a review, see ref. 1). Either adenoviruses or herpes viruses can act as helpers (2–5) . In the absence of a helper virus, AAV efficiently integrates into host cell chromosomes via its inverted ...
N, Muzyczka +4 more
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Linkage and Association to Genetic Markers
2015Genetic markers that are sufficiently polymorphic (as measured by their heterozygosities) can be used in linkage and association analyses to detect Mendelian segregation underlying disease phenotypes. Each type of analysis can either be based on a specific genetic model or not make any assumptions about the mode of inheritance of the disease ...
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