Results 261 to 270 of about 2,782,325 (342)

The phenotypic and genetic association between endometriosis and immunological diseases. [PDF]

Hum Reprod
Shigesi N, Harris HR, Fang H, Ndungu A, Lincoln MR, International Endometriosis Genome Consortium, 23andMe Research Team, Cotsapas C, Knight J, Missmer SA, Morris AP, Becker CM, Rahmioglu N, Zondervan KT.   +13 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Editorial: Genetic association studies in oil seeds

Frontiers in Genetics
V. G. Shobhana, Silvas J. P. Kirubakaran, Song Li, T. P. Parthiban   +3 more
doaj   +1 more source

Genetic association of proinflammatory cytokines in the pathogenesis of frailty syndrome: an application of ordinal logistic regression model. [PDF]

BMC Geriatr
Juárez-Cedillo T, Martínez-Rodríguez N, Rocha-Cruz A, Fragoso JM, Robles-Ramírez RJ, Juárez-Cedillo E.   +5 more
europepmc   +1 more source

GBS-based marker–trait association and genetic mapping for enhanced QTL significance in apricot progenies (<i>Prunus armeniaca</i> L.)

Juan Alfonso Salazar, Germán Ortuño-Hernández, Manuel C. Rubio, P. Martínez‐Gómez, David Ruiz   +4 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Genetic Association of Primary Angle-Closure Glaucoma and Disease Progression. [PDF]

Clin Exp Ophthalmol
Liang YJ, Ling A, Chan PP, Yam JC, Pang CP, Tham CC, Chen LJ.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Genetic association of lipids characteristics and lipid lowering drug target genes with sepsis. [PDF]

PLoS One
Wang Y, Zhang H, Zhan Y, Li Z, Li S, Zhang Y, Guo S.   +6 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source