Results 301 to 310 of about 8,825,337 (378)
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Nature Genetics, 2019 R. Karlsson Linnér, Pietro Biroli, Edward Kong, S. Meddens, R. Wedow, M. Fontana, M. Lebreton, Stephen P. Tino, A. Abdellaoui, Anke R. Hammerschlag, M. Nivard, A. Okbay, C. A. Rietveld, P. Timshel, M. Trzaskowski, R. Vlaming, C. Zünd, Y. Bao, Laura Buzdugan, Ann H. Caplin, Chia-Yen Chen, P. Eibich, P. Fontanillas, J. González, Peter K. Joshi, V. Karhunen, A. Kleinman, R. Levin, C. Lill, Gerardus A. Meddens, G. Muntané, S. Sanchez-Roige, F. J. Rooij, E. Taskesen, Yang Wu, Futao Zhang, Michelle Babak Robert K. Katarzyna Sarah L. Nicholas A. Kar Agee Alipanahi Bell Bryc Elson Furlotte Huber Litt, M. Agee, B. Alipanahi, R. Bell, K. Bryc, S. Elson, N. Furlotte, K. Huber, N. Litterman, J. McCreight, M. Mcintyre, J. Mountain, C. Northover, S. Pitts, J. Sathirapongsasuti, O. Sazonova, J. Shelton, S. Shringarpure, C. Tian, J. Tung, V. Vacic, C. H. Wilson, Mawussé Habibul Isabel Anand Philip Alexis Frank Marc Dorr Agbessi Ahsan Alves Andiappan Awadalla Battle Beut, M. Agbessi, H. Ahsan, I. Alves, A. Andiappan, P. Awadalla, A. Battle, F. Beutner, Marc Jan Bonder, D. Boomsma, M. Christiansen, A. Claringbould, Patrick Deelen, T. Esko, M. Favé, L. Franke, T. Frayling, S. Gharib, G. Gibson, B. Heijmans, G. Hemani, R. Jansen, M. Kähönen, A. Kalnapenkis, S. Kasela, J. Kettunen, Yungil Kim, H. Kirsten, P. Kovacs, K. Krohn, J. Kronberg-Guzman, V. Kukushkina, Z. Kutalik, Bernett Lee, T. Lehtimäki, M. Loeffler, U. Marigorta, A. Metspalu, L. Milani, G. Montgomery, M. Müller-Nurasyid, M. Nauck, M. Nivard, B. Penninx, M. Perola, N. Pervjakova, B. Pierce, J. Powell, H. Prokisch, B. Psaty, O. Raitakari, S. Ring, S. Ripatti, Olaf Rotzchke, S. Rüeger, A. Saha, M. Scholz, K. Schramm, I. Seppälä, M. Stumvoll, P. Sullivan, P. Hoen, A. Teumer, J. Thiery, L. Tong, A. Tönjes, J. Dongen, J. Meurs, J. Verlouw, P. Visscher, U. Völker, U. Võsa, H. Westra, H. Yaghootkar, Jian Yang, B. Zeng, Aysu Jonathan P. Mark Alan James J. Tune H. Cornelius A Okbay Beauchamp Fontana Lee Pers Rietveld Turley C, A. Okbay, J. Beauchamp, James J. Lee, T. Pers, C. A. Rietveld, P. Turley, Guo-Bo Chen, V. Emilsson, Sven Oskarsson, Joseph K. Pickrell, Kevin Thom, P. Timshel, Ronald de Vlaming, T. Ahluwalia, J. Bacelis, C. Baumbach, G. Bjornsdottir, J. Brandsma, M. P. Concas, J. Derringer, T. Galesloot, G. Girotto, Richa Gupta, Leanne M. Hall, S. Harris, E. Hofer, M. Horikoshi, J. Huffman, Kadri Kaasik, I. Kalafati, R. Karlsson, A. Kong, J. Lahti, S. J. Lee, C. D. de Leeuw, P. Lind, K. Lindgren, Tian Liu, M. Mangino, J. Marten, E. Mihailov, Michael B. Miller, P. J. Most, C. Oldmeadow, A. Payton, W. Peyrot, Yong Qian, R. Rueedi, E. Salvi, B. Schmidt, Katharina E. Schraut, Jianxin Shi, A. Smith, R. Poot, B. S. Pourcain, G. Thorleifsson, N. Verweij, D. Vuckovic, J. Wellmann, Jingyun Yang, Wei Zhao, Zhihong Zhu, B. Alizadeh, N. Amin, A. Bakshi, S. Baumeister, G. Biino, K. Bønnelykke, P. Boyle, H. Campbell, F. Cappuccio, G. Davies, J. De Neve, P. Deloukas, I. Demuth, Jun Ding, L. Eisele, N. Eklund, David M. Evans, J. Faul, M. Feitosa, A. Forstner, I. Gandin, Bjarni Gunnarsson, B. Halldórsson, T. Harris, A. Heath, L. Hocking, E. Holliday, G. Homuth, M. Horan, J. Hottenga, P. D. De Jager, A. Jugessur, M. Kaakinen, S. Kanoni, Liisa Keltigangas-Järvinen, L. Kiemeney, I. Kolčić, S. Koskinen, A. Kraja, M. Kroh, A. Latvala, L. Launer, M. Lebreton, D. Levinson, P. Lichtenstein, P. Lichtner, D. Liewald, A. Loukola, P. Madden, R. Mägi, T. Mäki-Opas, R. Marioni, P. Marques-Vidal, George Mcmahon, C. Meisinger, T. Meitinger, Y. Milaneschi, Ronny Myhre, C. Nelson, D. Nyholt, W. Ollier, A. Palotie, L. Paternoster, N. Pedersen, K. Petrovic, D. Porteous, K. Räikkönen, S. Ring, A. Robino, Olga Rostapshova, I. Rudan, A. Rustichini, V. Salomaa, A. Sanders, Antti-Pekka Sarin, H. Schmidt, R. Scott, Blair H. Smith, Jennifer A. Smith, J. Staessen, E. Steinhagen-Thiessen, K. Strauch, A. Terracciano, M. Tobin, Sheila Ulivi, S. Vaccargiu, L. Quaye, C. Venturini, Anna A. E. Vinkhuyzen, H. Völzke, J. Vonk, D. Vozzi, Johannes Waage, E. Ware, G. Willemsen, J. Attia, D. Bennett, K. Berger, L. Bertram, H. Bisgaard, I. Borecki, U. Bültmann, C. Chabris, F. Cucca, D. Cusi, I. Deary, G. Dedoussis, C. Duijn, J. Eriksson, B. Franke, P. Gasparini, P. Gejman, C. Gieger, H. Grabe, J. Gratten, P. Groenen, V. Gudnason, P. Harst, C. Hayward, D. Hinds, W. Hoffmann, E. Hyppönen, W. Iacono, B. Jacobsson, M. Järvelin, K. Jöckel, J. Kaprio, S. Kardia, Steven F. Lehrer, P. Magnusson, N. Martin, M. McGue, N. Pendleton, N. Pirastu, M. Pirastu, O. Polašek, D. Posthuma, C. Power, M. Province, N. Samani, D. Schlessinger, R. Schmidt, T. Sørensen, T. Spector, K. Stefánsson, U. Thorsteinsdóttir, A. Thurik, N. Timpson, H. Tiemeier, A. Uitterlinden, V. Vitart, P. Vollenweider, D. Weir, James F. Wilson, A. Wright, D. Conley, R. Krueger, G. Smith, A. Hofman, David Laibson, S. Medland, M. Meyer, M. Johannesson, P. Koellinger, D. Cesarini, D. Benjamin, A. Auton, J. Boardman, D. Clark, Andrew Conlin, Conora Dolan, U. Fischbacher, K. Harris, G. Hasler, M. Ikram, Sonia Jain, R. Karlsson, R. Kessler, M. Kooyman, J. Mackillop, M. Männikkö, C. Morcillo-Suarez, M. McQueen, Klaus M. Schmidt, M. Smart, Matthias Sutter, A. Thurik, Jon White, H. Wit, Jian Yang, E. Fehr, D. Hinds, M. Johannesson, M. Kumari, David Laibson, P. Magnusson, A. Navarro, A. Palmer, D. Posthuma, D. Schunk, M. Stein, R. Svento, H. Tiemeier, P. Timmers, R. Ursano, G. Wagner, James F. Wilson, James J. Lee, D. Benjamin, J. Beauchamp +406 moresemanticscholar +1 more sourceInvestigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov +10 morewiley +1 more sourceThe influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients
Molecular Oncology, EarlyView.This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken +8 morewiley +1 more sourceGenetic association of the kynurenine pathway to suicidal behavior. [PDF]
Brain Behav Immun HealthTamimou R, Montout C, Mura T, Conejero I, Evrard A, Courtet P, Bonilla-Escribano P, Riaza C, Vaquero-Lorenzo C, Baca-Garcia E, Jollant F, Lumbroso S, Mouzat K, Lopez-Castroman J. +13 moreeuropepmc +1 more sourceYAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna +9 morewiley +1 more sourceEmerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger +3 morewiley +1 more source
