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Biological Psychiatry, 2007
Genetic association studies are widely used in biomedical research and yet only a minority of positive findings stand the test of replication. I explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication.Genetically realistic simulation data of a typical genotyping/analytic ...
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Genetic association studies are widely used in biomedical research and yet only a minority of positive findings stand the test of replication. I explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication.Genetically realistic simulation data of a typical genotyping/analytic ...
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Genetic Variations and Association
2010Publisher Summary This chapter provides information about the human hydroxytryptamine (HT)R6 gene structure, its evolution, and its expression profile in both the brain and in peripheral tissues. The chapter describes the regulatory regions like binding sites for transcription factors (TFs) or for miRNA.
GENNARELLI, Massimo, CATTANEO, Annamaria
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2006
AbstractThis chapter focuses on genetic association studies. The goal of genetic association studies is to investigate the effects of genotypic variation on disease risk. These designs are built on a concept of a genetic cause that closely resembles the concept of a risk factor in epidemiology.
Ezra Susser +3 more
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AbstractThis chapter focuses on genetic association studies. The goal of genetic association studies is to investigate the effects of genotypic variation on disease risk. These designs are built on a concept of a genetic cause that closely resembles the concept of a risk factor in epidemiology.
Ezra Susser +3 more
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Cell journal, 2015
Population-based genetic association studies have proven to be a powerful tool in identifying genes implicated in many complex human diseases that have a huge impact on public health.
Atefeh Namipashaki +2 more
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Population-based genetic association studies have proven to be a powerful tool in identifying genes implicated in many complex human diseases that have a huge impact on public health.
Atefeh Namipashaki +2 more
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The Biomedical & Life Sciences Collection, 2009
Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
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Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
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2014
In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
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In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
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From Genetic Association to Genetic Switch
Science, 2008Human genetic studies have led to the identification of a transcriptional regulator that could serve as a therapeutic target for adult hemoglobin disorders.
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2016
Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide ...
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Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide ...
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Association genetics in crop improvement
Current Opinion in Plant Biology, 2010Increased availability of high throughput genotyping technology together with advances in DNA sequencing and in the development of statistical methodology appropriate for genome-wide association scan mapping in presence of considerable population structure contributed to the increased interest association mapping in plants. While most published studies
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