Results 141 to 150 of about 2,429,135 (273)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Polymorphisms in Corticotrophin-releasing Hormone-proopiomelanocortin (CRH-POMC) System Genes are Associated with Plaque Psoriasis

Acta Dermato-Venereologica, 2019
Tanel Traks, Maris Keermann, Maire Karelson, Ranno Rätsep, Ene Reimann, Helgi Silm, Eero Vasar, Sulev Kõks, Külli Kingo   +8 more
doaj   +1 more source

Review and further developments in statistical corrections for Winner's Curse in genetic association studies. [PDF]

PLoS Genet, 2023
Forde A, Hemani G, Ferguson J.
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Introduction to Genetic Association Studies [PDF]

Journal of Investigative Dermatology, 2007
Tsao, Hensin, Florez, Jose C.
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

BRASS: Permutation methods for binary traits in genetic association studies with structured samples. [PDF]

PLoS Genet, 2023
Mbatchou J, Abney M, McPeek MS.
europepmc   +1 more source

Genes, Economics, and Happiness [PDF]

We explore the influence of genetic variation on subjective well-being by employing a twin design and genetic association study. In a nationally-representative twin sample, we first show that about 33% of the variation in life satisfaction is explained ...
Bruno S. Frey, James H. Fowler, Jan-Emmanuel De Neve, Nicholas A. Christakis   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

GeneRiskCalc: a web-based tool for genetic risk association analysis in case–control studies

BMC Bioinformatics
Background Genetic association studies play a pivotal role in identifying disease-associated variants, but researchers face challenges in performing essential calculations like Hardy–Weinberg equilibrium testing, odds ratios, and confidence intervals due
Amrit Sudershan, Kuljeet Singh, Parvinder Kumar   +2 more
doaj   +1 more source