Results 161 to 170 of about 1,290,197 (259)

Genetic association studies using disease liabilities from deep neural networks. [PDF]

Am J Hum Genet
Yang L, Sadler MC, Altman RB.
europepmc   +1 more source

Genetic Association Studies of Age-Related Traits: New Perspectives. [PDF]

Adv Geriatr Med Res, 2021
Kulminski AM.
europepmc   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition. [PDF]

Sci Rep, 2021
Brandes N, Linial N, Linial M.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Asymptotically exact fit for linear mixed model in genetic association studies. [PDF]

Genetics
Guan Y, Levy D.
europepmc   +1 more source

Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse. [PDF]

Int Urogynecol J, 2022
Allen-Brady K, Chua JWF, Cuffolo R, Koch M, Sorrentino F, Cartwright R.   +5 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Association of Brain-derived Neurotrophic Factor Polymorphisms With Alcohol Use Disorder: An Updated Meta-Analysis of Genetic Association Studies. [PDF]

Brain Behav
Jenwitheesuk A, Pabalan N, Tapanadechopone P, Jarjanazi H, Arunphalungsanti K, Tharabenjasin P.   +5 more
europepmc   +1 more source

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision. [PDF]

Elife, 2021
Watson JA, Ndila CM, Uyoga S, Macharia A, Nyutu G, Mohammed S, Ngetsa C, Mturi N, Peshu N, Tsofa B, Rockett K, Leopold S, Kingston H, George EC, Maitland K, Day NP, Dondorp AM, Bejon P, Williams TN, Holmes CC, White NJ.   +20 more
europepmc   +1 more source