Results 141 to 150 of about 1,290,197 (259)

Diabetes Enters Stage Right: Genetic Association Studies Suggest Diabetes Promotes Pulmonary Hypertension and Right Ventricular Dysfunction. [PDF]

J Am Heart Assoc, 2023
Kazmirczak F, Prins KW.
europepmc   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Nonlinear kernel-based high-dimensional inference for set-based genetic association studies. [PDF]

Brief Bioinform
Zhang Z, Yang H, Zhu M, Guo R, Chen F, Dong H, Cui Y, Yang H.   +7 more
europepmc   +1 more source

Benchmarking statistical methods for analyzing parent-child dyads in genetic association studies. [PDF]

Genet Epidemiol, 2022
Ray D, Vergara C, Taub MA, Wojcik G, Ladd-Acosta C, Beaty TH, Duggal P.   +6 more
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Advancing drug development for systemic sclerosis by prioritizing findings from human genetic association studies. [PDF]

Rheumatology (Oxford)
Hughes M, McMahan ZH, Assassai S, Denton CP, Providencia R.   +4 more
europepmc   +1 more source

Toll-like receptor 9 (-1237 T/C, -1486 T/C) and the risk of gastric cancer: a meta-analysis of genetic association studies. [PDF]

BMC Cancer, 2023
Qyi YZ, Aung HH, Aye SN, Tung WS, Naing C.   +4 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

SPAmix: a scalable, accurate, and universal analysis framework for large-scale genetic association studies in admixed populations. [PDF]

Genome Biol
Ma Y, Xu H, Li Y, Kim H, Xu LL, Miao L, Xu P, Mao F, Zhou XJ, Zhou W, Lee S, Zhang JF, Zhang P, Bi W.   +13 more
europepmc   +1 more source

Inference for set-based effects in genetic association studies with interval-censored outcomes. [PDF]

Biometrics, 2023
Sun R, Zhu L, Li Y, Yasui Y, Robison L.
europepmc   +1 more source