Results 171 to 180 of about 2,429,135 (273)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Benchmarking statistical methods for analyzing parent-child dyads in genetic association studies. [PDF]

Genet Epidemiol, 2022
Ray D, Vergara C, Taub MA, Wojcik G, Ladd-Acosta C, Beaty TH, Duggal P.   +6 more
europepmc   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

SPAmix: a scalable, accurate, and universal analysis framework for large-scale genetic association studies in admixed populations. [PDF]

Genome Biol
Ma Y, Xu H, Li Y, Kim H, Xu LL, Miao L, Xu P, Mao F, Zhou XJ, Zhou W, Lee S, Zhang JF, Zhang P, Bi W.   +13 more
europepmc   +1 more source

Incorporating family disease history and controlling case-control imbalance for population-based genetic association studies. [PDF]

Bioinformatics, 2022
Zhuang Y, Wolford BN, Nam K, Bi W, Zhou W, Willer CJ, Mukherjee B, Lee S.   +7 more
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Genetic association studies in critically ill patients: a systematic review. [PDF]

EBioMedicine
Zhang W, Nguyen-Hoang N, Rivrud SCS, Zandbergen AF, Yan Y, Cox EGM, Suarez-Pajes E, Chong AY, Mentzer AJ, Flores C, Lunter G, Keus F, Snieder H.   +12 more
europepmc   +1 more source

Adjusting for collider bias in genetic association studies using instrumental variable methods. [PDF]

Genet Epidemiol, 2022
Cai S, Hartley A, Mahmoud O, Tilling K, Dudbridge F.   +4 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches. [PDF]

Endocrinol Diabetes Metab
Hostnik B, Tonin G, Janež A, Klen J.
europepmc   +1 more source