Results 281 to 290 of about 10,408,543 (352)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Valdivia Project: genetic characterization of a unique Wolfram Syndrome cluster in coastal Ecuador. [PDF]

Orphanet J Rare Dis
Palacio JE, Verdesoto MS, Bautista NL, Segura AJ, Cedeño RC, Flores NJ, Zevallos JC.   +6 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

First Molecular Detection and Genetic Characterization of Porcine Circovirus 5 in Diagnostic Swine Samples from China. [PDF]

Vet Sci
Zhang JQ, Li JX, Qu HL, Miao YJ, Chen XM, Zheng LL, Li YL, Chen HY, Ma SJ.   +8 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Molecular Epidemiology and Genetic Characterization of Feline Panleukopenia Virus among Clinically Suspected Domestic Cats in Tamil Nadu, India. [PDF]

Microorganisms
Paramasivam R, Vijayalakshmi R, Saminathan M, Parthiban M, Vinitha V, Chandrasekar M, Naveenkumar V, Nair A, Nabiya F, Saravanan S, Sekar D, Raj GD.   +11 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Expanded clinical and genetic characterization of autosomal recessive HMGCR-related muscular dystrophy. [PDF]

J Neuromuscul Dis
El-Hayek S, Rad A, Sedighzadeh S, Yesil G, Sabbagh S, Shahrooei M, Nair P, Gedikbaşı A, Bizzari S, Ali M, Chouery E, Mehawej C, Aslanger A, Rohani P, Sharifzadeh M, Akbas S, Mohammadi-Asl J, Behnam M, Corbani S, Karaman V, Yiş U, Oktay Y, Polat I, Urtizberea JA, Houlden H, Maroofian R, Oprea G, Megarbane A.   +27 more
europepmc   +1 more source

Genetic Characterization of Yellow Fever Virus Strain JSS, the Original South American Strain. [PDF]

Viruses
Lee ME, Hansen CA, Thompson JK, Hao H, Bourne N, Barrett ADT.   +5 more
europepmc   +1 more source