Results 91 to 100 of about 6,409 (231)

MOESM1 of Estimation of genetic connectedness diagnostics based on prediction errors without the prediction error varianceâ covariance matrix

, 2017
Additional file 1: Figure S1. A pdf file containing figures showing the differences in PEVMean between when H as opposed to A was used to model $$Var({{\bf u}})$$ V a r ( u ) . First column is diagonal elements, second column is off-diagonal elements. The red line indicates where the element of PEVMean was equal if either H and A was used.
Holmes, John, Dodds, Ken, Lee, Michael
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Influence Of Specialisation On Connectedness And Genetic Parameters In Dutch Warmblood Riding

, 2014
During the last decades, a process of specialisation into show jumping (JH) and dressage (DH) has been taking place in the Dutch Warmblood studbook (KWPN). The objectives of this paper were to describe the evolution of the connectedness between JH and DH over the last 15 years and to analyse the change in genetic parameters for some traits in JH and DH.
Rovere, Gabriel Alejandro, Madsen, Per, Norberg, Elise, Arendonk, Johan A M, Ducro, Bart J   +4 more
openaire   +1 more source

MOESM2 of Estimation of genetic connectedness diagnostics based on prediction errors without the prediction error varianceâ covariance matrix

, 2017
Additional file 1: Figure S2. A pdf file containing figures showing the relationship between flock harmonic mean and the CR when flock correlation is below 0.01 and A was used. The left hand side is model 2, the right side is model 3.
Holmes, John, Dodds, Ken, Lee, Michael
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Study of the Effect of Connectedness on Genetic Trend [PDF]

Journal of Animal and Veterinary Advances, 2012
openaire   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Long‐distance dispersal in the short‐distance dispersing house sparrow (Passer domesticus)

Ecology and Evolution
The house sparrow (Passer domesticus) is a small passerine known to be highly sedentary. Throughout a 30‐year capture–mark–recapture study, we have obtained occasional reports of recoveries far outside our main metapopulation study system, documenting ...
Peter S. Ranke, Michael L. Pepke, Jørgen S. Søraker, Gabriel David, Yimen G. Araya‐Ajoy, Jonathan Wright, Ådne M. Nafstad, Bernt Rønning, Henrik Pärn, Thor Harald Ringsby, Henrik Jensen, Bernt‐Erik Sæther   +11 more
doaj   +1 more source