Results 231 to 240 of about 4,605,118 (350)

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

Genomic signatures of population isolation in an endangered European rodent. [PDF]

BMC Genomics
Byerly PA, von Thaden A, Rolshausen G, Cocchiararo B, Erhardt S, Fietz J, Frantz AC, Kramer EM, Stubbe SP, Vinciguerra L, Winter S, Lang J, Meinig H, Büchner S, Nowak C.   +14 more
europepmc   +1 more source

Systematic conservation planning for intraspecific genetic diversity

Proceedings of the Royal Society B: Biological Sciences, 2018
Ivan Paz‐Vinas, G. Loot, V. Hermoso, Charlotte Veyssière, Nicolas Poulet, G. Grenouillet, S. Blanchet   +6 more
semanticscholar   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Genetic diversity in Cyatheaceae in a stressful changing climate: a multi-omics review of adaptive evolution and conservation. [PDF]

Front Genet
Li T, Cong H, Rao D, Wu E, Cui Y, Gan R, Khan MN, Chen Y.   +7 more
europepmc   +1 more source

From working collections to the World Germplasm Project: agricultural modernization and genetic conservation at the Rockefeller Foundation. [PDF]

Hist Philos Life Sci, 2017
Curry HA.
europepmc   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Conservation and exploitation status of skate species (Batoidea: Rajidae) in the Balearic Islands, western Mediterranean. [PDF]

PLoS One
Ferragut-Perello F, Ramírez-Amaro S, Petit-Marty N, Farriols MT, Quetglas A, Guijarro B, Ordines F.   +6 more
europepmc   +1 more source

The importance of considering genetic diversity in shark and ray conservation policies

Conservation Genetics, 2017
R. Domingues, A. Hilsdorf, O. B. Gadig
semanticscholar   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source