Results 91 to 100 of about 1,867,301 (331)

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Estimates of Genetic and Phenotypic Trends of Growth Traits in Bali Cattle [PDF]

open access: yes, 2012
The aim of this study was to estimate genetic and phenotypic trends for growth traits including birth (BW), weaning (WW) and yearling weight (YW) in Bali cattle.
Gunawan, A. (A)   +2 more
core  

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Genetic analysis and qtl mapping of agro-morphological traits in lowland rice (Oryza sativa L.) under drought conditions [PDF]

open access: yes, 2016
The present study was undertaken to evaluate lowland rice genetic variability associated with agro-morphological traits under drought condition. A set of 250 recombinant inbred lines (RILs) from the cross between rice parental cultivarIR64 (sensitive to ...
Audebert, Alain   +6 more
core  

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Variance and covariance components for liability of piglet survival during different periods

open access: yesAnimal, 2008
Variance and covariance components for piglet survival in different periods were estimated from individual records of 133 004 Danish Landrace piglets and 89 928 Danish Yorkshire piglets, using a liability threshold model including both direct and ...
G. Su, D. Sorensen, M.S. Lund
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

The causal relationship between type 2 diabetes mellitus and isolated REM sleep behavior disorder: results from multivariable and network Mendelian randomization analysis

open access: yesFrontiers in Endocrinology
ObjectivesTo investigate the causal relationship between type 2 diabetes mellitus (T2DM, exposure) and isolated REM sleep behavior disorder (iRBD, outcome).MethodsGenome-wide association study (GWAS) data for iRBD comprised 9,447 samples, including 1,061
Ru-Yu Zhang   +7 more
doaj   +1 more source

Genetic selection for temperament traits in dairy and beef cattle

open access: yesFrontiers in Genetics, 2014
Animal temperament can be defined as a response to environmental or social stimuli. There are a number of temperament traits in cattle that contribute to their welfare, including their response to handling or milking, response to challenge such as human ...
Marie J Haskell   +2 more
doaj   +1 more source

Cultural Inheritance, Gender, and Intergenerational Occupational Mobility: Evidence from a Developing Economy [PDF]

open access: yes
This paper presents evidence on intergenerational occupational mobility from agriculture to the nonfarm sector using survey data from Nepal with a focus on the role played by cultural inheritance and gender norms.
Forhad Shilpi, M. Shahe Emran
core  

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