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Oligodendrogliomas: clinical and genetic correlations
Current Opinion in Neurology, 2001Oligodendrogliomas, once obscure, are now recognized as a relatively common form of primary brain tumour, and are among the most chemosensitive of all solid human malignancies. New histopathological, molecular, and genetic information has, for the first time, allowed the distinction of several subtypes of human glioma with predictable biological and ...
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Genetic Correlations with Multiple Alleles
Biometrics, 1960Hogben [1932] gave the values for filial and fraternal correlations for matings involving two alleles in a panmictic population. The subject has been considered in great detail by Li [1955], but the known results are restricted to the case of two alleles. Consequently, if it is desired to compare a correlation derived from actual experimental data with
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ESTABLISHING GENETIC CORRELATIONS INVOLVING PARASITE VIRULENCE
Evolution, 1998For many host-parasite interactions, virulence is necessarily affected by population densities, transmission biology of the parasite, and proliferation of the parasite at the expense of its host. Attempts to experimentally demonstrate genetic correlations involving virulence therefore need to employ protocols controlling for variation in the number of ...
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Estimating genetic correlations from inbred strains
Behavior Genetics, 1981Genetic correlations measure the extent of pleiotropic effects of polygenes on pairs of characters or the closeness of linkage between sets of loci influencing the traits and held in allelic (gametic) disequilibrium. Their importance for research lies primarily in predicting correlated responses of one trait to selection based on values for another ...
J P, Hegmann, B, Possidente
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1997
The last chapter examined the genetic basis of the resemblance between parents and offspring for a single trait. However, it is common experience that traits are not inherited as independent units, but that several traits tend to be associated with each other.
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The last chapter examined the genetic basis of the resemblance between parents and offspring for a single trait. However, it is common experience that traits are not inherited as independent units, but that several traits tend to be associated with each other.
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Nonrandom Sampling in Human Genetics: Familial Correlations
Mathematical Medicine and Biology, 1984In the context of human genetics, sampling is often nonrandom in that pedigrees are frequently selected by virtue of their having at least one affected individual. For quantitative traits, it may be that the proband is selected because of a phenotypic value above some predetermined cut-point; this will also be true for diseases defined by a cut-point ...
Hanis, Craig L., Chakraborty, Ranajit
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Assortative mating and the genetic correlation
Theoretical and Applied Genetics, 1982The effect of assortative mating on the genetic correlation between traits X and Y is considered. Assortation on trait X changes the magnitude of the genetic correlation but not its sign. There are two situations depending on the signs of the correlation between mates (ρ) and of the random mating genetic correlation (θ): 1) if sign (θ) = sign (ρ), then
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Further remarks on estimating genetic correlations
Annals of Human Genetics, 1980SummaryA method of estimating correlations between relatives given in a previous paper in Annals of Human Genetics has been further explored, explained, and illustrated by examples.
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Genetic Correlates of Treatment-Resistant Depression
JAMA PsychiatryImportanceTreatment-resistant depression (TRD) is a major challenge in mental health, affecting a significant number of patients and leading to considerable burdens. The etiological factors contributing to TRD are complex and not fully understood.ObjectiveTo investigate the genetic factors associated with TRD using polygenic scores (PGS) across various
Bohan, Xu +9 more
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14. DECOMPOSING GENETIC CORRELATIONS
European Neuropsychopharmacology, 2022Christiaan de Leeuw +2 more
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