Results 271 to 280 of about 7,428,370 (340)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Leisure-Time Physical Activity, Sedentary Behavior, and Biological Aging: Evidence From Genetic Correlation and Mendelian Randomization Analyses. [PDF]

Scand J Med Sci Sports
Zhao X, Wu X, He L, Xiao J, Xiang R, Sha L, Tang M, Hao Y, Qu Y, Xiao C, Qin C, Hou J, Deng Q, Zhu J, Zheng S, Zhou J, Yu T, Yang B, Song X, Han T, Liao J, Zhang T, Fan M, Li J, Jiang X.   +24 more
europepmc   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating. [PDF]

Am J Hum Genet
Ma S, Wang F, Border R, Buxbaum J, Zaitlen N, Ionita-Laza I.   +5 more
europepmc   +1 more source

Genetic correlation, heritability and possibilities of early multilocal selection for yield estimation of winter wheat

, 1989
Philippe Brabant, Yann Manès, Maxime Trottet, Elise Picard   +3 more
openalex   +1 more source

Correlation of Morphologic and Cytogenetic Parameters of Genetic Instability With Chromosomal Alterations in In Situ Carcinomas of the Breast

, 2000
Horst Buerger, Ellen C.M. Mommers, Ruth Littmann, Raihanatou Diallo, C. Brinkschmidt, Christopher Poremba, Barbara Dockhorn‐Dworniczak, P. J. van Diest, W. Böcker   +8 more
openalex   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Clinico-radiological findings of men 2A syndrome and its genetic correlation: A case report with review of literature. [PDF]

Radiol Case Rep
Singhal N, Shukla S, Mishra N, Sherwani P, Babu J.   +4 more
europepmc   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source