Results 101 to 110 of about 3,272,002 (311)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Estimation of genetic associations between reproduction and production traits based on a sire and dam line with common ancestry

Animal, 2009
Genetic parameters for survival, reproduction and production traits were estimated for a sire and dam line, originating from one Large White breed separated more than 25 years ago.
D.N.R.G. Kapell, C.J. Ashworth, G.A. Walling, A.B. Lawrence, S.A. Edwards, R. Roehe   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Estimate of Genetic Parameters for Pre-Weaning Growth Traits and Kleiber Ratio in Palestinian Sheep Breeds

Agriculture
Data on 1440 Awassi (AW), 2114 Assaf (AF), 261 Crossbred (XB), and 439 Improved Awassi (IA) lamb genotypes from 689 AW, 1009 AF, 105 XB, and 195 IA dams, and 152 sires, obtained from three geographical districts in the West Bank and collected between ...
Muayad Salman, Ikram Ben Souf, Samia Khnissi, Wael Halaweh, Naceur M’Hamdi   +4 more
doaj   +1 more source

Genetic correlations in the rhesus macaque dentition

Journal of Human Evolution, 2020
Quantitative genetic analyses can indicate how complex traits respond to natural selection by demonstrating the genetic relationships between features that constrain their evolution. Genetic correlations between dental measurements have been estimated previously in baboons, humans, and tamarins and indicate variable patterns of modularity by tooth type
openaire   +3 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Heritabilities (diagonal), genetic (top) and phenotypic (bottom) correlations.

, 2014
Heritabilities (diagonal), genetic (top) and phenotypic (bottom) correlations.
William Barendse (184999), Jose Fernando Garcia (4390906), John M. Henshall (665115), Kishore C. Prayaga (665110), Geoffry Fordyce (665113), Tad S. Sonstegard (175161), David J. Johnston (665111), Eva K. F. Chan (209476), Laercio R. Porto-Neto (523652), Sigrid A. Lehnert (665116), Heather M. Burrow (665114), Michael E. Goddard (252450), Sunduimijid Bolormaa (543860), Rachel J. Hawken (665112), Antonio Reverter (61185)   +14 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

PARÁMETROS GENÉTICOS PARA CARACTERÍSTICAS REPRODUCTIVAS EN UNA POBLACIÓN DE BÚFALOS (BUBALUS BUBALIS ARTIODACTYLA, BOVIDAE) EN EL MAGDALENA MEDIO COLOMBIANO GENETIC PARAMETERS FOR REPRODUCTIVE TRAITS IN A POPULATION OF BUFFALOES (BUBALUS BUBALIS ARTIODACTYLA: BOVIDAE) IN THE MIDDLE MAGDALENA REGION OF COLOMBIA

Revista Facultad Nacional de Agronomía Medellín, 2010
La investigación se hizo para estimar los componentes de (co)varianza y parámetros genéticos para edad al primer parto (EPP) e intervalo entre partos (IEP) en una población bufalina en el Magdalena Medio Colombiano.
Diana María Bolívar Vergara, Edison Julián Ramírez Toro, Divier Antonio Agudelo Gómez, Roberto Arturo Angulo Arroyave, Mario Fernando Cerón Muñoz   +4 more
doaj