Results 81 to 90 of about 3,272,002 (311)

Cardiac Defects and Genetic Syndromes: Old Uncertainties and New Insights

, 2021
Recent advances in understanding the genetic causes and anatomic subtypes of cardiac defects have revealed new links between genetic etiology, pathogenetic mechanisms and cardiac phenotypes.
Flaminia Pugnaloni, Fabrizio Drago, Giulio Calcagni, Francesca Piceci Sparascio, Marco Tartaglia, Maria Cristina Digilio, Carolina Putotto, Marta Unolt, Alessandro De Luca, Bruno Marino, Paolo Versacci, Marcello Niceta, Anwar Baban   +12 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Estimates of (co)variance components and genetic parameters for body weights and growth efficiency traits in the New Zealand white rabbit

World Rabbit Science, 2017
The genetic parameters of growth traits in the New Zealand White rabbits kept at Sheep Breeding and Research Station, Sandynallah, The Nilgiris, India were estimated by partitioning the variance and covariance components.
M. Sakthivel, D. Balasubramanyam, P. Kumarasamy, H. Gopi, A. Raja, R. Anilkumar, A. Devaki   +6 more
doaj   +1 more source

The genetic relationship between commencement of luteal activity and calving interval, body condition score, production, and linear type traits in Holstein-Friesian dairy cattle [PDF]

, 2002
The decline of fertility in the UK dairy herd and the unfavorable genetic correlation (r(a)) between fertility and milk yield has necessitated the broadening of breeding goals to include fertility.
Flint, APF, Pryce, J.E., Woolliams, JA, Royal, M.D., Pryce, JE, Flint, A.P.F., Woolliams, John, Royal, MD   +7 more
core  

Results of genetic correlations between age-classes for ejaculate size.

, 2015
Genetic correlations in bold were not significantly different from 0.Results of genetic correlations between age-classes for ejaculate size.
Alexandre Robert (192668), Gwénaëlle Leveque (776174), Céline Teplitsky (2910893), Anne Charmantier (532107), Frédéric Lacroix (342825), Stéphane Chantepie (776173), Yves Hingrat (342824), Gabriele Sorci (288219)   +7 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Needle‐ and Canopy‐Level Genetic Variation in Scots Pine (Pinus sylvestris L.) Revealed by Hyperspectral Phenotyping Across Sites and Seasons

Evolutionary Applications
As an essential species across European forests, Scots pine (Pinus sylvestris L.) plays a vital ecological and economic role, yet its physiological variability underlying its adaptive potential remains underexplored.
Daniel Provazník, Jan Stejskal, Zuzana Lhotáková, Jaroslav Čepl, Eva Neuwirthová, Adenan Yandra Nofrizal, Jiří Korecký, Lucie Červená, Lucie Kupková, Jaroslav Klápště, Jon Kehlet Hansen, Salvador A. Gezan, Petya Campbell, Milan Lstibůrek, Jana Albrechtová   +14 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source