Results 131 to 140 of about 7,495,262 (331)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

Nature Human Behaviour, 2019
Genetic correlations estimated from genome-wide association studies (GWASs) reveal pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural equation modelling (genomic SEM): a multivariate method for analysing the joint ...
A. Grotzinger, M. Rhemtulla, R. Vlaming, R. Vlaming, Stuart J. Ritchie, T. Mallard, W. Hill, Hill F. Ip, R. Marioni, A. McIntosh, I. Deary, P. Koellinger, P. Koellinger, K. Harden, M. Nivard, E. Tucker-Drob   +15 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Dairy cattle breeding objectives combining production and non-production traits for pasture based systems in Ireland. [PDF]

, 2005
End of Project ReportThe objectives of this study were: 1) to estimate genetic (co) variances among body condition score, body weight, milk production, linear type traits and fertility, and 2) to investigate the presence of genotype by environment ...
Berry, Donagh, Buckley, Frank, Dillon, Pat, Veerkamp, Roel F.   +3 more
core  

Japanese quail meat quality: characteristics, heritabilities, and genetic correlations with some slaughter traits.

Poultry Science, 2013
The aim of this study was to evaluate the genetic parameters of several breast meat quality traits and their genetic relationships with some slaughter traits [BW, breast yield (BRY), and abdominal fat yield (AFY)].
D. Narinç, T. Aksoy, E. Karaman, A. Aygun, M. Firat, M. Uslu   +5 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Needle‐ and Canopy‐Level Genetic Variation in Scots Pine (Pinus sylvestris L.) Revealed by Hyperspectral Phenotyping Across Sites and Seasons

Evolutionary Applications
As an essential species across European forests, Scots pine (Pinus sylvestris L.) plays a vital ecological and economic role, yet its physiological variability underlying its adaptive potential remains underexplored.
Daniel Provazník, Jan Stejskal, Zuzana Lhotáková, Jaroslav Čepl, Eva Neuwirthová, Adenan Yandra Nofrizal, Jiří Korecký, Lucie Červená, Lucie Kupková, Jaroslav Klápště, Jon Kehlet Hansen, Salvador A. Gezan, Petya Campbell, Milan Lstibůrek, Jana Albrechtová   +14 more
doaj   +1 more source

GENETIC COVARIANCE OF FITNESS CORRELATES: WHAT GENETIC CORRELATIONS ARE MADE OF AND WHY IT MATTERS [PDF]

Evolution, 1991
The genetic variance-covariance matrix, G, is determined in part by functional architecture, the pathways by which variation in genotype influences phenotype. I develop a simple architectural model for G for two traits under directional selection constrained by their dependence on a common limiting resource. I assume that genetic variance is maintained
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source