Results 141 to 150 of about 7,495,262 (331)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Aplicação do método Bayesiano na estimação de correlações genéticas e fenotípicas de peso em codornas de corte em várias idades Application of the Bayesian method to estimate genetic and phenotypic parameters of growth traits of meat quails

open access: yesRevista Brasileira de Zootecnia, 2006
Objetivou-se com este estudo obter estimativas de correlações genéticas e fenotípicas para características peso aos 7 dias (PES7), peso aos 14 dias (PES14), peso aos 28 dias (PES28) e peso aos 42 dias de idade (PES42) de codornas de corte.
Eliane Maria Wilbert Winter   +5 more
doaj   +1 more source

Mechanistic Information and Causal Continuity [PDF]

open access: yes, 2010
Some biological processes (our examples are DNA expression and a reflex response in the leech) move from step to step in a way that cannot be completely understood solely in terms of causes and correlations.
Bogen, Jim, Machamer, Peter
core  

On the Sampling Variance of Intraclass Correlations and Genetic Correlations [PDF]

open access: yesGenetics, 1998
Abstract Widely used standard expressions for the sampling variance of intraclass correlations and genetic correlation coefficients were reviewed for small and large sample sizes. For the sampling variance of the intraclass correlation, it was shown by simulation that the commonly used expression, derived using a first-order Taylor ...
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Estimate of Genetic Parameters for Pre-Weaning Growth Traits and Kleiber Ratio in Palestinian Sheep Breeds

open access: yesAgriculture
Data on 1440 Awassi (AW), 2114 Assaf (AF), 261 Crossbred (XB), and 439 Improved Awassi (IA) lamb genotypes from 689 AW, 1009 AF, 105 XB, and 195 IA dams, and 152 sires, obtained from three geographical districts in the West Bank and collected between ...
Muayad Salman   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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