Results 91 to 100 of about 2,249,426 (311)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Sudden shift to remote genetic counseling during the COVID-19 pandemic: Experiences of genetics professionals in Italy

, 2021
The 2020 COVID-19 pandemic has rendered in-person provision of genetic counseling impossible for prolonged periods in many countries, mandating a sudden shift to remote delivery.
Battistuzzi L., Bertonazzi B., Godino L., Turchetti D.   +3 more
core   +1 more source

'Now it's your choice': Nondirective genetic counseling, other minds, place and counselee empowerment [PDF]

, 2020
In this article we use a variety of philosophical literature to support and clarify the tenets and importance of a form of nondirective genetic counseling.
Crowden, Andrew, Gildersleeve, Matthew
core   +1 more source

Genomic insights into familial adenomatous polyposis: unraveling a rare case with whole APC gene deletion and intellectual disability

Human Genome Variation
A young patient diagnosed with advanced colon cancer and liver metastasis was found to have familial adenomatous polyposis (FAP) through comprehensive genomic analysis.
Hiroki Tanabe, Masami Ijiri, Kenji Takahashi, Honoka Sasagawa, Tomomi Kamanaka, Shohei Kuroda, Hiroki Sato, Takeo Sarashina, Yusuke Mizukami, Yoshio Makita, Toshikatsu Okumura   +10 more
doaj   +1 more source

Cancer genetic counselling

Annals of Oncology, 2005
No abstract ...
MANDICH P, CAVALLI P, PASINI, Barbara
openaire   +4 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Tuberous sclerosis: Clinical evaluation in a family and implications for genetic counseling

, 1998
Tuberous Sclerosis: Clinical evaluation of a family and implications for generic counseling: Tuberous sclerosis is an autosomal-dominant neurocutaneous disease, characterized by hamartomas in various organs.
Elcioglu, M, Nuhoglu, A, Cenani, A, Elcioglu, N, Karatekin, G   +4 more
core  

Genetic counselling [PDF]

BMJ, 1988
J G, Thornton, R J, Lilford
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Bibliometric analysis of genetic counseling publications in Asia: Insights and implications

Genetics in Medicine Open
Purpose: Investigation of genetic counseling-related published papers offers a historical assessment of the cumulative scientific knowledge produced by members of the profession and can be the basis for future practice, training, and research. This paper
Peter James B. Abad, Ma-Am Joy R. Tumulak, Sook-Yee Yoon, Mercy Y. Laurino, Qurratulain Hasan   +4 more
doaj   +1 more source