Results 121 to 130 of about 3,117,325 (331)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Fundamentos clínicos del consejo genético en cáncer hereditario

Psicooncologia, 2005
We describe the Genetic Counseling as the translation of the hereditary cancer knowledge to the clinical practice. Genetic counseling is a process for information, which takes place at the Genetic Counseling Units, where individual cancer risk and ...
Ana López, Enrique Lastra, Beatriz Nieto, María García, Cristina Bayona, Eva Fonseca, Blanca Hernando, Rosario Hernández, Carlos García-girón   +8 more
doaj  

NIPT Integration as a Patient-Paid Prenatal Screening Option—Observations and Challenges from a Bulgarian Genetic Counseling Center [PDF]

Dinnar Yahya, Mari Hachmeriyan, Milena Stoyanova, Mariya Levkova   +3 more
openalex   +1 more source

Developing my Preferred Model of Genetic Counselling [PDF]

, 2011
Matthew Burgess
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Prenatal Diagnosis and Genetic Counseling for Niemann-Pick C Disease

, 2015
Mohsen Javadzadeh
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Genetic counseling of fetal microcephaly

Journal of Medical Ultrasound
Fetal microcephaly is a small head with various losses of cerebral cortical volume. The affected cases may suffer from a wide range in severity of impaired cerebral development from slight to severe mental retardation.
Shu-Chin Chien, Chih-Ping Chen
doaj   +1 more source

URGENT DIAGNOSIS IN PRACTICAL GENETIC COUNSELLING

, 1991
L Vasileva, Десислава Kонстантинова   +1 more
openalex   +2 more sources

Adaptation and preliminary validation of the genetic counseling outcome scale (GCOS-24) in a Brazilian genetic counseling setting

, 2020
Mayara Segundo Ribeiro, Bruna Tavares Bacalá, Willyane de Andrade Alvarenga, Lucila Castanheira Nascimento, Marion McAllister, Milena Flória‐Santos   +5 more
openalex   +2 more sources