Results 141 to 150 of about 2,373,878 (316)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Fundamentos clínicos del consejo genético en cáncer hereditario

Psicooncologia, 2005
We describe the Genetic Counseling as the translation of the hereditary cancer knowledge to the clinical practice. Genetic counseling is a process for information, which takes place at the Genetic Counseling Units, where individual cancer risk and ...
Ana López, Enrique Lastra, Beatriz Nieto, María García, Cristina Bayona, Eva Fonseca, Blanca Hernando, Rosario Hernández, Carlos García-girón   +8 more
doaj  

Exploring Factors That Impact Genetic Counseling Referral and Uptake Using Learning Health Approaches

Learning Health Systems
Introduction Germline testing and pretest genetic counseling are advised for many cancer patients, yet not all receive these services. Electronic Health Records (EHRs) offer a valuable resource to measure referral to genetic counseling (referral receipt)
Samantha Greenberg, Bob Wong, Katherine A. Sward, Kathleen A. Cooney, Jonathan Tward, Andrew Post, Mollie R. Cummins   +6 more
doaj   +1 more source

Genetic Counseling and Genetic Testing for Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is one of the most common autosomal codominant Mendelian diseases. The major complications of FH include tendon and cutaneous xanthomas and coronary artery disease (CAD) associated with a substantial elevation of serum ...
Tomoko Sekiya, Atsushi Watanabe, Masayuki Takamura, Hayato Tada, Masa-aki Kawashiri, Atsushi Nohara   +5 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Genetic counseling in the Middle East: provider perspectives of patient attitudes and cultural challenges

Human Genomics
Genomic advancements have led to increased utilization of genetic testing in clinical care, yet barriers to accessing genetic counseling and genomics services remain, particularly in the Middle East where inherited diseases are highly prevalent due to ...
Shruti Shenbagam, Alan Taylor, Ruchi Jain, Khalid Fakhro, Fowzan Alkuraya, Ahmad Abou Tayoun   +5 more
doaj   +1 more source

A rare case of aniridia and balanced translocation (5;11) (p15.3; q22) arising in the same subject: A challenge for genetic counseling

, 2015
A rare case of aniridia and balanced translocation (5:11)(p15.3;q22) arising in the same subject: et challenge for genetic counseling: The authors report on a case of isolated aniridia caused by haploinsufficiency of the PAX6 gene, which is located on ...
Maciel-Guerra, AT, Vulcan-Freitas, TM
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An exploration of delegation practices regarding the utilization of genetic counseling assistants for disclosure of genetic testing results

Genetic counselors (GCs) play a crucial role in the healthcare system, providing education, support and guidance regarding genetic risk assessment, testing and results interpretation. To help GCs practice at the highest level of their expertise, the role
Stone, Kristyne, Allison, Camille O., Wetherill, Leah, Delk, Paula R., Ranson, David   +4 more
core   +1 more source