Results 161 to 170 of about 2,249,426 (311)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Knowledge of cancer genetics and attitudes about genetic counseling and testing: a randomized trial of the Know Your Risk intervention compared to conventional genetic counseling. [PDF]

Cancer Causes Control
Katz ML, Schnell PM, Reiter PL, Senter L, Aeilts A, Spears C, Cooper J, Brown J, Shane-Carson KP, Agnese DM, Toland AE, Sweet K.   +11 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

When generations meet: navigating nondisclosure preimplantation genetic testing for Huntington's disease

F&S Reports
Amber Kaplun, M.S., C.G.C.
doaj   +1 more source

Genetic counseling of ventricular tachycardias

Anatolian Journal of Cardiology, 2021
Hande Kaymakçalan Çelebiler
doaj   +1 more source

Still Becoming: Global Reflections on the Future of the Genetic Counseling Profession. [PDF]

J Genet Couns
Ribeiro B, Guimarães L, Pirzadeh-Miller S, Fitzpatrick J, McEwen A, Paneque M.   +5 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Whither consumer credit counseling? [PDF]

Bob Hunt outlines the history of credit counseling in the U.S. He also observes that, despite its long track record, the credit counseling industry is not without controversy.
Robert M. Hunt
core  

Performance and limitations of four large language models in genetic counseling for thalassemia. [PDF]

Front Digit Health
Zhong W, Huang J, Wei M, Liang Q, Yang Y, Chen J, Mao J, Qin Y, Sun Y, Liang Y.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source