Results 191 to 200 of about 3,117,325 (331)

A Nationwide Survey Investigating the Current Status of Genetic Counseling in Newborn Screening in Japan. [PDF]

Int J Neonatal Screen
Sakai E, Yamada T, Hamazaki T, Tajima G, Seto T.   +4 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Investigation on the Anxiety and Depression Status of Thalassemia Carriers After Genetic Counseling. [PDF]

Neuropsychiatr Dis Treat
Pan J, Xu A, Tung TH, Shen B.
europepmc   +1 more source

Atlas of Genetic Diagnosis and Counseling [PDF]

, 2006
Harold Chen
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Achieving cultural safety in genetic counseling for Aboriginal and Torres Strait Islander people in Australia. [PDF]

J Genet Couns
Wadling B, Gaff C, Barclay J, Brown A.
europepmc   +1 more source

A method to assess the organizing behaviors used in physicians’ counseling of standardized parents after newborn genetic screening

, 2013
Stephanie Christopher, Nadia Ahmad, Lisa Bradford, Jenelle L. Collins, Kerry L. Eskra, Alison La Pean Kirschner, Faith O. O’Tool, Sara J. Roedl, Michael H. Farrell   +8 more
openalex   +2 more sources

Barriers to participating in genetic counseling and BRCA testing during primary treatment for breast cancer [PDF]

, 2007
Kathryn J. Schlich‐Bakker, H.F.J. ten Kroode, Carla C. Wárlám-Rodenhuis, Jan van den Bout, Margreet G.E.M. Ausems   +4 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source