Results 231 to 240 of about 27,774 (298)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Virulence determinants and toxin profile of methicillin resistant Staphylococcus aureus from commercial cheese in Bangladesh: A public health risk. [PDF]

PLoS One
Hossain MT, Fahim FJ, Rana S, Sultana N, Uddin MS, Uddin MN, Noor M, Khatun A, Zinnah KMA, Ara A, Hossain FMA.   +10 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Past and present genetic structure of the tropical rainforest palm <i>Astrocaryum mexicanum</i>: effects of anthropogenic fragmentation. [PDF]

PeerJ
Juárez-Ramírez JO, Núñez-Farfán J.
europepmc   +1 more source

The Efficacy of the Fitzpatrick Scale in Clinical Practice. [PDF]

HCA Healthc J Med
Olsen D, Nguyen C, Hall M, Carletti M, Weis SE.   +4 more
europepmc   +1 more source

Current perspectives on risk prediction and genetic basis of Brugada syndrome. [PDF]

Front Cardiovasc Med
Bhardwaj P, Stavnem D, Jacobsen SB, Winkel BG, Tfelt-Hansen J.   +4 more
europepmc   +1 more source

Intergenerational healthcare ethics: considering conceptualizations of generations and their collective and temporal dimensions. [PDF]

Med Health Care Philos
Ellerich-Groppe N, Bozzaro C, Koesling D, Rehmann-Sutter C, Schicktanz S, Schweda M.   +5 more
europepmc   +1 more source

Theoretical Discussion of Applicability and a Practical Example of Using Statistical Second-Generation Techniques to Analyze Causal Relationships in Animal Experiments. [PDF]

Animals (Basel)
Katrin B.
europepmc   +1 more source

A scoping review on the mental health of disaster responders for natural disasters in Japan. [PDF]

PCN Rep
Ito Y, Takahashi S, Tachikawa H, Midorikawa H, Arai T.   +4 more
europepmc   +1 more source