Results 121 to 130 of about 544,097 (312)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Genetic layout and genetic structure of the greenhouse whitefly Trialeurodes vaporariorum from Serbia

, 2019
Trialeurodes vaporariorum Westwood (Hemiptera: Aleyrodidae), a haplo-diploid sap feeding insect species, is a vector of many plant viruses and a serious polyphagous pest of greenhouse-grown vegetables and ornamental plants worldwide.
Drobnjaković, Tanja, Marčić, Dejan, Prijović, Mirjana, Banjanac, Tijana, Aleksić, Jelena   +4 more
core  

Identification of a new COQ4 spliceogenic variant causing severe primary coenzyme Q deficiency

Molecular Genetics and Metabolism Reports
Background and aims: Primary Coenzyme Q (CoQ) deficiency caused by COQ4 defects is a clinically heterogeneous mitochondrial condition characterized by reduced levels of CoQ10 in tissues. Next-generation sequencing has lately boosted the genetic diagnosis
María Alcázar-Fabra, Elsebet Østergaard, Daniel J.M. Fernández-Ayala, María Andrea Desbats, Valeria Morbidoni, Laura Tomás-Gallado, Laura García-Corzo, María del Mar Blanquer-Roselló, Abigail K. Bartlett, Ana Sánchez-Cuesta, Lucía Sena, Ana Cortés-Rodríguez, María Victoria Cascajo-Almenara, David J. Pagliarini, Eva Trevisson, Sabine W. Gronborg, Gloria Brea-Calvo   +16 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Diagnostics and therapeutic insights in a severe case of mevalonate kinase deficiency

, 2007
Mevalonate kinase deficiency is a rare inborn disorder of isoprenoid and sterol biosynthesis characterized by a recurrent autoinflammatory syndrome and, in most severe cases, psychomotor delay.
Nevyjel, Marco, Waterham, Hans R., Barbi, Egidio, Pontillo, Alessandra, Tommasini, Alberto, Marilena Granzotto, Granzotto, Marilena, Alessandra Pontillo, Andrea D'Osualdo, Egidio Barbi, Lorenzo Calligaris, Alberto Tommasini, Sergio Crovella, D'Osualdo, Andrea, Alessandro Ventura, Calligaris, Lorenzo, Crovella, Sergio, Ventura, Alessandro, Marco Nevyjel, Hans R. Waterham   +19 more
core   +1 more source

Genetic deficiency of protein inhibitor of activated STAT3 suppresses experimental abdominal aortic aneurysms. [PDF]

Front Cardiovasc Med, 2023
Fu W, Liu H, Wei P, Xia C, Yu Q, Tian K, Li Y, Liu E, Xu B, Miyata M, Wang R, Zhao S.   +11 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Evaluation of predictive tests for screening for dihydropyrimidine dehydrogenase deficiency

, 2013
5-Fluorouracil (5-FU) is rapidly degraded by dihyropyrimidine dehydrogenase (DPD). Therefore, DPD deficiency can lead to severe toxicity or even death following treatment with 5-FU or capecitabine.
Guchelaar, H.J., Jan Guchelaar, H., Gelderblom, H., van Kuilenburg, A. B. P., Maring, J.G., Staveren, M.C. van, Kuilenburg, A.B.P. van, van Staveren, M. C., Maring, J. G.   +8 more
core   +1 more source

Genetic deficiency and pharmacological modulation of RORα regulate laser-induced choroidal neovascularization. [PDF]

Aging (Albany NY), 2023
Liu CH, Yemanyi F, Bora K, Kushwah N, Blomfield AK, Kamenecka TM, SanGiovanni JP, Sun Y, Solt LA, Chen J.   +9 more
europepmc   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source