The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A Perspective on Accelerated Aging Caused by the Genetic Deficiency of the Metabolic Protein, OPA1. [PDF]
Front Neurol, 2021 Erchova I, Sun S, Votruba M.
europepmc +1 more source
FACTOR VII DEFICIENCY DURING PREGNANCY
, 2013 Factor VII deficiency is a genetic disorder of coagulation and inherited as autosomal recessive. Although inherited disorders of coagulation are rare, Factor VII deficiency is the most common among them.
TURĞAL, MERT +6 more
core +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
RIDDLE syndrome ring finger protein 168 deficiency in a 9-month-old boy from Jazan, Saudi Arabia
Saudi Journal for Health SciencesThis study explores the intricate challenges of ring finger protein 168 (RNF168) deficiency, an uncommon genetic disorder characterized by immunodeficiency, radiation sensitivity, and diverse clinical traits.
Abdullah H Alhamoud +4 more
doaj +1 more source
Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model. [PDF]
Int J Mol Sci, 2022 Arora A +12 more
europepmc +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia. [PDF]
Adv Sci (Weinh), 2022 Zhou C +9 more
europepmc +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Genetic Deficiency of p53 Leads to Structural, Functional, and Synaptic Deficits in Primary Somatosensory Cortical Neurons of Adult Mice. [PDF]
Front Mol Neurosci, 2022 Kuang H +10 more
europepmc +1 more source