Results 91 to 100 of about 851,546 (305)

On the clinical picture and diagnosis of rare neurological diseases [PDF]

Саратовский научно-медицинский журнал, 2018
 The article presents clinical observation of patient H, 2007 year of birth., with X-linked adrenoleukodystrophy (X-ALD). This is a rare hereditary metabolic disease, not only in Russia but also worldwide.
Ulyanova O.V., Kutashov V.A., Brezhneva N.V.   +2 more
doaj  

Proceedings of the COST SUSVAR/ECO-PB Workshop on organic plant breeding strategies and the use of molecular markers [PDF]

, 2005
In many countries,national projects are in progress to investigate the sustainable low-input approach.In the present COST network,these projects are coordinated by means of exchange of materials,establishing common methods for assessment and statistical ...

core  

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis [PDF]

, 2014
In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested.
, Airó, Paolo, Alarcón-Riquelme, Marta, AlKassab, Firas, Arnett, Frank C., Assassi, Shervin, Baron, Murray, Beretta, Lorenzo, Bossini-Castillo, Lara, Broen, Jasper, Brown, Matthew, Carmona, Francisco David, Carreira, Patricia, Castellví, Iván, Chen, Wei V., Denton, Christopher, Distler, Jörg H.W., Docherty, Peter, Fessler, Barri J., Fonseca, Carmen, Frech, Tracy M., Furst, Daniel E., González-Gay, Miguel Ángel, Gorlova, Olga, Gregersen, Peter K., Guerra, Sandra, Herrick, Ariane, Hesselstrand, Roger, Hinchcliff, Monique E., Hudson, Marie, Hummers, Laura K., Hunzelmann, Nicolas, Jones, Henry Niall, Kaminska, Elzbieta, Khalidi, Nader, Khanna, Dinesh, Koeleman, Bobby P., Kreuter, Alexander, Lafyatis, Robert A., Lee, Annette T., Lunardi, Claudio, López-Isac, Elena, Markland, Janet, Martin, Javier, Martin, José Ezequiel, Mayes, Maureen D., Molitor, Jerry A., Nordin, Annika, Ochoa, Eguzkine, Padyukov, Leonid, Phillips, Kristin, Pope, Janet E., Radstake, Timothy R.D.J., Reveille, John D., Riemekasten, Gabriela, Robinson, David, Schiopu, Elena, Schuerwegh, Annemie J., Segal, Barbara M., Shiels, Paul, Silver, Richard M., Simeón, Carmen Pilar, Simms, Robert W., Steen, Virginia D., Tan, Filemon K., Teruel, María, van Laar, Jacob M., Varga, John, Voskuyl, Alexandre E., Wigley, Fredrick M., Wijmenga, Cisca, Witte, Torsten, Worthington, Jane, Ying, Jun, Zhernakova, Alexandra, Zhou, Xiaodong   +75 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Although the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across Africa has not been attempted.
A-Elbasit, Ishraga E, Agboghoroma, Chris O, Barnes, Karen I, Bonnet, Maryline, Bâ, El-Hadj, Chanda, Pascalina, Chandramohan, Daniel, Cissé, Badara, Clarke, Sian, Dejene, Seyoum, Diallo, Diadier A, Dunyo, Samuel, Elegba, Olufunmilayo Y, Evehe, Marie-Solange B, Getachew, Asefaw, Giha, Hayder A, Grobusch, Martin P, Guthmann, Jean-Paul, Hawela, Moonga, Inojosa, Walter, Kachur, S Patrick, Katokele, Stark T, Kweku, Margaret, Lynch, Caroline, Malisa, Allen L, Matondo, Alexandre, Mbacham, Wilfred, Mombo-Ngoma, Ghyslain, Naidoo, Inbarani, Njie, Fanta, Ord, Rosalynn, Owusu-Agyei, Seth, Pearce, Richard J, Pota, Hirva, Roper, Cally, Rwakimari, John B, Sharp, Brian, Streat, Elizabeth, Swarthout, Todd D, Uusiku, Petrina, van den Broek, Ingrid V   +40 more
core   +5 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Cone Dysfunction Syndromes [PDF]

, 2016
The cone dysfunction syndromes are a heterogeneous group of inherited, predominantly stationary retinal disorders characterised by reduced central vision, and varying degrees of colour vision abnormalities, nystagmus and photophobia.
Aboshiha, J, Carroll, J, Dubis, AM, Harcastle, AJ, Michaelides, M   +4 more
core  

Molecular Infectious Disease Epidemiology: Survival Analysis and Algorithms Linking Phylogenies to Transmission Trees

, 2016
Recent work has attempted to use whole-genome sequence data from pathogens to reconstruct the transmission trees linking infectors and infectees in outbreaks.
Britton, Tom, Halloran, M. Elizabeth, Kenah, Eben, Longini Jr, Ira M.   +3 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source