Results 71 to 80 of about 11,144,186 (305)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Newborn Screening for X-Linked Adrenoleukodystrophy (X-ALD): Biochemical, Molecular, and Clinical Characteristics of Other Genetic Conditions

The state of California (CA) added X-linked adrenoleukodystrophy (X-ALD) to newborn screening (NBS) in 2016 via the measurement of C26:0-lysophosphatidylcholine (C26:0-LPC) in a two-tier fashion, followed by sequencing of the ABCD1 gene.
Annie D. Niehaus, Rebecca Sponberg, Jose E. Abdenur, Richard Chang, Christina G. Tise, Carlos F. Mares Beltran, Gregory M. Enns, Rebekah Barrick   +7 more
core   +1 more source

When sex matters: a complete model of X-linked diseases

, 2018
X-linked recessive diseases are genetic disorders caused by gene's abnormalities placed on the X chromosome. Due to differences between males and females in sex chromosomes, the transmission mechanisms of these diseases vary in the two sexes.
Glielmo, L., Verrilli, F., L. Glielmo, F. Verrilli, C. Del Vecchio, Del Vecchio, C.   +5 more
core   +1 more source

Genetic Variants behind Cardiovascular Diseases and Dementia

, 2020
Cardiovascular diseases (CVDs) and dementia are the leading causes of disability and mortality. Genetic connections between cardiovascular risk factors and dementia have not been elucidated.
Yah-Yuan Wu, Yi-Chun Chen, Wei-Min Ho
core   +1 more source

X-Linked Adrenoleukodystrophy in a Moroccan Patient: Genetic Diagnosis Leads to Presymptomatic Testing and Family Counseling

Balkan Journal of Medical Genetics
X-linked adrenoleukodystrophy (X-ALD) is a fatal neurodegenerative disorder caused by mutations in the adenosine triphosphate-binding cassette D1 (ABCD1) gene. In this study, we report the case of a Moroccan patient diagnosed with X-ALD due to a mutation
Mansouri M, Smol T, Louhabe N, Rama M, Rada N, Fdil N, Bouskraoui M, Aboussair N   +7 more
doaj   +1 more source

Flow cytometry-based diagnosis of primary immunodeficiency diseases

Allergology International, 2018
Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly.
Hirokazu Kanegane, Akihiro Hoshino, Tsubasa Okano, Takahiro Yasumi, Taizo Wada, Hidetoshi Takada, Satoshi Okada, Motoi Yamashita, Tzu-wen Yeh, Ryuta Nishikomori, Masatoshi Takagi, Kohsuke Imai, Hans D. Ochs, Tomohiro Morio   +13 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]

, 2011
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
Polonikov, Alexey, Wichmann, Heinz-Erich, Fabian J. Theis, Stephan Weidinger, Wichmann Heinz Erich, Gieger, C., Ried, Janina S., Christian Gieger, Krumsiek, J., Karsten Suhre, Prehn, C., Kirstin Mittelstrass, Heinz Erich Wichmann, Polonikov, A., Weidinger, S., Alexey Polonikov, Werner Roemisch-Margl, Yu Zhonghao, Theis, F.J., Wang-Sattler, R., Jan Krumsiek, Ried Janina S., Yu, Z., Gieger Christian, Mittelstrass, Kirstin, Wichmann, H.-E., Polonikov Alexey, Illig, T., Fabian J Theis, Peters, Annette, Illig Thomas, Mittelstrass Kirstin, Zhonghao Yu, Theis, Fabian J., Peters Annette, Kronenberg Florian, Florian Kronenberg, Jerzy Adamski, Annette Peters, Wang-Sattler, Rui, Krumsiek, Jan, Theis Fabian J., Peters, A., Krumsiek Jan, Illig, Thomas, Roemisch-Margl Werner, Wang-Sattler Rui, Meitinger, Thomas, Adamski, Jerzy, Ried, J.S., Cornelia Prehn, Thomas Illig, Römisch-Margl, W., Suhre Karsten, Gieger, Christian, Weidinger, Stephan, Weidinger Stephan, Suhre, K., Roemisch-Margl, Werner, Kronenberg, Florian, Yu, Zhonghao, Adamski Jerzy, Thomas Meitinger, Meitinger, T., Prehn, Cornelia, Rui Wang-Sattler, Kronenberg, F., Janina S. Ried, Prehn Cornelia, Adamski, J., Mittelstraß, K., Suhre, Karsten, Janina S Ried, Meitinger Thomas, Mittelstrass, K;Ried, JS;Yu, Z;Krumsiek, J;Gieger, C;Prehn, C;Roemisch-Margl, W;Polonikov, A;Peters, A;Theis, FJ;Meitinger, T;Kronenberg, F;Weidinger, S;Wichmann, HE;Suhre, K;Wang-Sattler, R;Adamski, J;Illig, T, Mittelstraß, K. ; Ried, J.S. ; Yu, Z. ; Krumsiek, J. ; Gieger, C. ; Prehn, C. ; Römisch-Margl, W. ; Polonikov, A. ; Peters, A. ; Theis, F.J. ; Meitinger, T. ; Kronenberg, F. ; Weidinger, S. ; Wichmann, H.-E. ; Suhre, K. ; Wang-Sattler, R. ; Adamski, J. ; Illig, T.   +75 more
core   +1 more source