Results 121 to 130 of about 554,004 (364)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Yeast Augmented Network Analysis (YANA): a new systems approach to identify therapeutic targets for human genetic diseases [v1; ref status: indexed, http://f1000r.es/3gk]

F1000Research, 2014
Genetic interaction networks that underlie most human diseases are highly complex and poorly defined. Better-defined networks will allow identification of a greater number of therapeutic targets.
David J. Wiley, Ilona Juan, Hao Le, Xiaodong Cai, Lisa Baumbach, Christine Beattie, Gennaro D'Urso   +6 more
doaj   +1 more source

A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy

, 2003
X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative and endocrine disorder resulting from mutations in ABCD1 which encodes a peroxisomal membrane protein in the ATP binding cassette superfamily.
Powers, James M., Lu, Jyh-Feng, Kemp, Stephan, Smith, Kirby D., Moser, Ann B., Mihalik, Stephanie, Heinzer, Ann K., Li, Yuan Yuan, Watkins, Paul A.   +8 more
core   +1 more source

Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases [PDF]

, 2014
Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining
Syed Tariq Sadiq, Nibali, L, Luigi Nibali, Henderson, B, Sadiq, ST, Brian Henderson, Donos, N, Nikos Donos   +7 more
core   +1 more source

Challenges in Gene Therapy for Somatic Reverted Mosaicism in X-Linked Combined Immunodeficiency by CRISPR/Cas9 and Prime Editing

, 2022
X-linked severe combined immunodeficiency (X-SCID) is a primary immunodeficiency that is caused by mutations in the interleukin-2 receptor gamma (IL2RG) gene.
Markus Mezger, Mezger, Markus, Gratz, Hans Peter, Ureña-Bailén, Guillermo, Alicia Roig-Merino, Roig-Merino, Alicia, Yujuan Hou, Handgretinger, Rupert, Tahereh Mohammadian Gol, Alberto Daniel-Moreno, Mohammadian Gol, Tahereh, Daniel-Moreno, Alberto, Antony, Justin S., Hans Peter Gratz, Rupert Handgretinger, Lamsfus-Calle, Andrés, Justin S. Antony, Hou, Yujuan, Andrés Lamsfus-Calle, Guillermo Ureña-Bailén, Paul Gerhard Gratz, Gratz, Paul Gerhard   +21 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy

Cells, 2019
Autophagy (self-eating) is a conserved cellular degradation process that plays important roles in maintaining homeostasis and preventing nutritional, metabolic, and infection-mediated stresses.
R. Khandia, Maryam Dadar, A. Munjal, K. Dhama, K. Karthik, R. Tiwari, M. I. Yatoo, Hafiz M.N. Iqbal, K. P. Singh, S. Joshi, W. Chaicumpa   +10 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Immune Dysregulation, Polyendocrinopathy and Enteropathy X-Linked Syndrome with Neonatal Onset: A Case Report

Acta Médica Portuguesa
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare monogenic autoimmune disorder caused by mutations in the FOXP3 gene. It typically presents in early infancy with severe multisystem autoimmunity.
Joana Costa Branco, Margarida Cunha, Ana Dias Curado, Inês Girbal, Isabel Esteves, Sandra Valente   +5 more
doaj   +1 more source

Você conhece esta síndrome? Do you know this syndrome?

Anais Brasileiros de Dermatologia, 2011
A síndrome de Goltz é uma doença genética rara, de herança dominante ligada ao X, mais comum em doentes do sexo feminino e, na maioria das vezes, resulta no aborto dos fetos do sexo masculino. Tem um amplo espectro de manifestações clínicas possíveis.
Izelda Maria Carvalho Costa, Isabel Irene Ramos Leal, Lilian Mendes Ferreira Urbano   +2 more
doaj   +1 more source