Results 131 to 140 of about 554,004 (364)

Translational research combining orthologous genes and human diseases with the OGOLOD dataset

, 2012
OGOLOD is a Linked Open Data dataset derived from different biomedical resources by an automated pipeline, using a tailored ontology as a scaffold.
Egaña Aranguren, Mikel, Miñarro-Giménez, José Antonio, Fernández-Breis, Jesualdo Tomás, Villazón-Terrazas, Boris   +3 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Coexisting genetic kidney disease explains many cases of ‘familial’ IgA nephropathy where the proband has biopsy-confirmed mesangial IgA deposits

Frontiers in Medicine
BackgroundOne in seven people with IgA nephropathy has another apparently-affected family member. This study examined how often biopsy-proven familial and sporadic IgA nephropathy were associated with genetic kidney disease.MethodsEleven unrelated people
YuXin Li, Jing Zhang, Zhuo Jun Yin, Ziming Zhou, Bocheng Huang, Khalid Mahmood, Deb Colville, David Barit, Russell Auwardt, Robert Fassett, Kathy Paizis, Francesco Ierino, Timothy Pianta, David Langsford, Mary Huang, Judy Savige   +15 more
doaj   +1 more source

Genetic analysis of candidate genes linked to atopic eczema in the Bangladeshi population of East London

, 2010
PhDBackground: Atopic Eczema (AE) is a common skin disease that results from a complex interplay between genetic and environmental factors. It may be associated with other atopic phenotypes including; asthma, hayfever and food allergy.
Al Kuwaiti, Rauda
core  

Kinetoplastids: related protozoan pathogens, different diseases. [PDF]

, 2008
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their
Gürtler, Ricardo E, Tarleton, Rick, Reed, Steve, Stuart, Ken, Guertler, Ricardo E., Fairlamb, Alan; id_orcid, Ken Stuart, Steve Reed, Brun, Reto, McKerrow, Jim, Jim McKerrow, Fairlamb, Alan, Ricardo E. Gürtler, Alan Fairlamb, Rick Tarleton, Reto Brun, Simon Croft, Croft, Simon   +17 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A novel approach to simulate gene-environment interactions in complex diseases [PDF]

, 2010
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc ...
Amato, Roberto, G. Raiconi, ROBERTO AMATO, Miele, Gennaro, Nicodemi Mario, D. D'Andrea, Amato Roberto, AND SERGIO COCOZZA, MARIO NICODEMI, MICHELE PINELLI, Nicodemi, Mario, D'Andrea Daniel, Pinelli, Michele, Sergio Cocozza, Raiconi, Giancarlo, GENNARO MIELE, Amato, R. (Roberto), Cocozza Sergio, Raiconi Giancarlo, Miele Gennaro, Giancarlo Raiconi, D’Andrea, Daniel, Cocozza, Sergio, Pinelli Michele, DANIEL D'ANDREA   +24 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The history of X-chromosome inactivation and relation of recent findings to understanding of human X-linked conditions

The Turkish Journal of Pediatrics, 1995
This paper represents the text of two lectures given on the occasion of a Workshop on the X-Chromosome held at Hacettepe University, Ankara, in September 1994.
M F Lyon
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source