Results 101 to 110 of about 12,192,107 (344)

Mosquito Innate Immunity

Insects, 2018
Mosquitoes live under the endless threat of infections from different kinds of pathogens such as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical and physiological barriers that resist the entry of the pathogen and
Ankit Kumar, Priyanshu Srivastava, PDNN Sirisena, Sunil Kumar Dubey, Ramesh Kumar, Jatin Shrinet, Sujatha Sunil   +6 more
doaj   +1 more source

Modeled Fetal Risk of Genetic Diseases Identified by Expanded Carrier Screening.

Journal of the American Medical Association (JAMA), 2016
IMPORTANCE Screening for carrier status of a limited number of single-gene conditions is the current standard of prenatal care. Methods have become available allowing rapid expanded carrier screening for a substantial number of conditions.
I. Haque, G. Lazarin, H. P. Kang, Eric A. Evans, J. Goldberg, R. Wapner   +5 more
semanticscholar   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

mRNA trans‐splicing in gene therapy for genetic diseases

Wiley Interdisciplinary Reviews - RNA, 2016
Spliceosome‐mediated RNA trans‐splicing, or SMaRT, is a promising strategy to design innovative gene therapy solutions for currently intractable genetic diseases.
Adeline Berger, Séverine Maire, M. Gaillard, J. Sahel, P. Hantraye, A. Bemelmans   +5 more
semanticscholar   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Opportunities for developing therapies for rare genetic diseases: focus on gain-of-function and allostery

Orphanet Journal of Rare Diseases, 2017
BackgroundAdvances in next generation sequencing technologies have revolutionized our ability to discover the causes of rare genetic diseases. However, developing treatments for these diseases remains challenging.
Binbin Chen, R. Altman
semanticscholar   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Analysis of deletional hereditary persistence of fetal hemoglobin/δβ‐thalassemia and δ‐globin gene mutations in Southerwestern China

Molecular Genetics & Genomic Medicine, 2019
Background Deletional hereditary persistence of fetal hemoglobin (HPFH)/δβ‐thalassemia and δ‐thalassemia are rare inherited disorders which may complicate the diagnosis of β‐thalassemia.
Jie Zhang, Yang Yang, Peng Li, Yuanlong Yan, Tao Lv, Tingting Zhao, Xiaohong Zeng, Dongmei Li, Xiaoyan Zhou, Hong Chen, Jie Su, Tonghua Yang, Jing He, Baosheng Zhu   +13 more
doaj   +1 more source

GemTools: A fast and efficient approach to estimating genetic ancestry [PDF]

arXiv, 2011
To uncover the genetic basis of complex disease, individuals are often measured at a large number of genetic variants (usually SNPs) across the genome. GemTools provides computationally efficient tools for modeling genetic ancestry based on SNP genotypes.
arxiv  

A 26-hour system of highly sensitive whole genome sequencing for emergency management of genetic diseases

Genome Medicine, 2015
While the cost of whole genome sequencing (WGS) is approaching the realm of routine medical tests, it remains too tardy to help guide the management of many acute medical conditions.
Neil A. Miller, E. Farrow, M. Gibson, L. Willig, Greyson Twist, B. Yoo, Tyler Marrs, Shane Corder, L. Krivohlavek, Adam M. Walter, J. Petrikin, Carol J. Saunders, I. Thiffault, S. Soden, Laurie D. Smith, D. Dinwiddie, Suzanne M. Herd, Julie A. Cakici, S. Catreux, M. Ruehle, S. Kingsmore   +20 more
semanticscholar   +1 more source