Results 101 to 110 of about 11,828,008 (230)
Scientific Reports, 2018 We generated cattle embryos using mitochondrial supplementation and somatic cell nuclear transfer (SCNT), named miNT, to determine how additional mitochondrial DNA (mtDNA) modulates the nuclear genome.
Kanokwan Srirattana, Justin C. St. John
doaj +1 more source
Disentangling genetic and environmental risk factors for individual diseases from multiplex comorbidity networks [PDF]
arXiv, 2016 Most disorders are caused by a combination of multiple genetic and/or environmental factors. If two diseases are caused by the same molecular mechanism, they tend to co-occur in patients. Here we provide a quantitative method to disentangle how much genetic or environmental risk factors contribute to the pathogenesis of 358 individual diseases ...
arxiv
Modeled Fetal Risk of Genetic Diseases Identified by Expanded Carrier Screening.
Journal of the American Medical Association (JAMA), 2016 IMPORTANCE Screening for carrier status of a limited number of single-gene conditions is the current standard of prenatal care. Methods have become available allowing rapid expanded carrier screening for a substantial number of conditions.
I. Haque +5 more
semanticscholar +1 more source
, 2009 This chapter first presents the interrelations between computing and genetics, which both are based on information and, particularly, self-reproducing artificial systems. It goes on to examine genetic code from a computational viewpoint.
Barreiro Sorrivas, Jose Maria +1 more
core +1 more source
HLA Class I or Class II and Disease Association: Catch the Difference if You Can [PDF]
, 2017 The association of autoimmune diseases with HLA has been known for many decades. To date, however, the underlying mechanisms have not been fully understood. The recently introduced genome-wide association studies (GWAS) have suggested that several genes
Fiorillo, Mt +3 more
core +2 more sources
mRNA trans‐splicing in gene therapy for genetic diseases
Wiley Interdisciplinary Reviews - RNA, 2016 Spliceosome‐mediated RNA trans‐splicing, or SMaRT, is a promising strategy to design innovative gene therapy solutions for currently intractable genetic diseases.
Adeline Berger +5 more
semanticscholar +1 more source
Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life
CellsTopoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ...
Kemin Tan, Yuk-Ching Tse-Dinh
doaj +1 more source
Molecular Genetics & Genomic Medicine, 2019 Background Deletional hereditary persistence of fetal hemoglobin (HPFH)/δβ‐thalassemia and δ‐thalassemia are rare inherited disorders which may complicate the diagnosis of β‐thalassemia.
Jie Zhang +13 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2017 BackgroundAdvances in next generation sequencing technologies have revolutionized our ability to discover the causes of rare genetic diseases. However, developing treatments for these diseases remains challenging.
Binbin Chen, R. Altman
semanticscholar +1 more source
Applications of gene modification technologies in the treatment of inherited diseases
Journal of Education, Health and SportIntroduction and Purpose: In last years gene modification technologies such as CRISPR/Cas9 has had a revolutionary impact on the treatment of inherited diseases.
Maciej Superson +6 more
doaj +1 more source