Results 231 to 240 of about 780,483 (315)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Inbreeding Implications on Genetic Diversity and Population Evolution of South American Brown Swiss Cattle. [PDF]

Vet Med Int
Cartuche-Macas LF, Gutierrez-Reinoso MA, Garcia-Herreros M.   +2 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

HIV-1 Genetic Diversity and Drug Resistance Mutations Among Patients on Antiretroviral Therapy in Nairobi County, Kenya. [PDF]

Adv Virol
Angiro E, Ngayo M, Wahome C, Mungiria J, Nyamache A.   +4 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Prevalence and Genetic Diversity of <i>Echinococcus granulosus</i> Sensu Stricto in Sheep from Kazakhstan. [PDF]

Biology (Basel)
Uakhit R, Tautanova A, Smagulova A, Hermosilla C, Abdybekova A, Abdybekova A, Lider L, Jazina K, Dusmagambetov M, Kiyan V.   +9 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Genetic Diversity Analysis and Core Collection Development of Indian Mungbean (<i>Vigna radiata</i>) Germplasm. [PDF]

Plants (Basel)
Dhasarathan M, Karthikeyan A, Samyuktha SM, Vishwanathan LJK, Ariharasutharsan G, Senthil N, Pandiyan M.   +6 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Genetic diversity and population structure of Passiflora spp. using inter-primer binding site (iPBS) - retrotransposon markers. [PDF]

Mol Biol Rep
de Jesus ON, Costa EMR, Azevedo FQ, de Sousa VR, Gonçalves ZS, Lima LKS, Soares TL.   +6 more
europepmc   +1 more source